Most-cited Genetics and Biochemistry papers of 2022, with free PDFs

The 25 most-cited Genetics and Biochemistry research papers published in 2022, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. ColabFold: making protein folding accessible to all
   Milot Mirdita, Konstantin Schütze et al. · 2022 · 9,505 citations · Free PDF
2. The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest
   Damian Szklarczyk, Rebecca L. Kirsch et al. · 2022 · 9,430 citations
3. UniProt: the Universal Protein Knowledgebase in 2023
   Alex G. Bateman, Maria Jesus Martin et al. · 2022 · 7,042 citations
4. DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)
   Brad T. Sherman, Ming Hao et al. · 2022 · 6,201 citations
5. KEGG for taxonomy-based analysis of pathways and genomes
   Minoru I. Kanehisa, Miho Furumichi et al. · 2022 · 5,778 citations
6. Copper induces cell death by targeting lipoylated TCA cycle proteins
   Peter Tsvetkov, Shannon Coy et al. · 2022 · 4,860 citations
7. Microbiota in health and diseases
   Kaijian Hou, Zhuo‐Xun Wu et al. · 2022 · 3,135 citations · Free PDF
8. The complete sequence of a human genome
   Sergey Nurk, Sergey Koren et al. · 2022 · 3,134 citations
9. SignalP 6.0 predicts all five types of signal peptides using protein language models
   Felix Teufel, José Juan Almagro Armenteros et al. · 2022 · 2,901 citations · Free PDF
10. YaHS: yet another Hi-C scaffolding tool
    Chenxi Zhou, Shane McCarthy et al. · 2022 · 2,479 citations · Free PDF
11. UALCAN: An update to the integrated cancer data analysis platform
    Darshan Shimoga Chandrashekar, Santhosh Kumar Karthikeyan et al. · 2022 · 2,457 citations
12. InterPro in 2022
    Typhaine Paysan‐Lafosse, Matthias Blum et al. · 2022 · 2,450 citations · Free PDF
13. Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
    Jiaqi Liu, Qing Xiao et al. · 2022 · 2,425 citations · Free PDF
14. CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database
    Brian P. Alcock, William Huynh et al. · 2022 · 2,396 citations
15. Gut microbiome and health: mechanistic insights
    Willem M. de Vos, Herbert Tilg et al. · 2022 · 2,363 citations · Free PDF
16. Search and sequence analysis tools services from EMBL-EBI in 2022
    Fábio Madeira, Matt Pearce et al. · 2022 · 2,324 citations
17. Therapeutic peptides: current applications and future directions
    Lei Wang, Nanxi Wang et al. · 2022 · 2,100 citations · Free PDF
18. GTDB-Tk v2: memory friendly classification with the genome taxonomy database
    Pierre-Alain Chaumeil, Aaron James Mussig et al. · 2022 · 2,081 citations · Free PDF
19. Robust deep learning–based protein sequence design using ProteinMPNN
    Justas Dauparas, Ivan V. Anishchenko et al. · 2022 · 2,070 citations · Free PDF
20. SignalP 6.0 predicts all five types of signal peptides using protein language models
    Felix Teufel, José Juan Almagro Armenteros et al. · 2022 · 1,939 citations
21. Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics
    Uttpal Anand, Abhijit Dey et al. · 2022 · 1,828 citations
22. Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays
    Ao Chen, Sha Liao et al. · 2022 · 1,767 citations
23. Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
    Jun Guo, Xiuqing Huang et al. · 2022 · 1,717 citations · Free PDF
24. The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource
    Elliot Sollis, Abayomi Mosaku et al. · 2022 · 1,656 citations
25. The role of ROS in tumour development and progression
    Eric C. Cheung, Karen H. Vousden · 2022 · 1,597 citations

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