Most-cited Genetics and Biochemistry papers of 2019, with free PDFs

The 25 most-cited Genetics and Biochemistry research papers published in 2019, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
   Yingyao Zhou, Bin Zhou et al. · 2019 · 14,653 citations · Free PDF
2. OrthoFinder: phylogenetic orthology inference for comparative genomics
   David Emms, Steven L. Kelly · 2019 · 7,690 citations · Free PDF
3. BioBERT: a pre-trained biomedical language representation model for biomedical text mining
   Jinhyuk Lee, Wonjin Yoon et al. · 2019 · 7,279 citations · Free PDF
4. Improved metagenomic analysis with Kraken 2
   Derrick E. Wood, Jennifer Lu et al. · 2019 · 7,155 citations · Free PDF
5. Interactive Tree Of Life (iTOL) v4: recent updates and new developments
   Ivica Letunić, Peer Bork B · 2019 · 5,988 citations
6. Toward understanding the origin and evolution of cellular organisms
   Minoru I. Kanehisa · 2019 · 5,503 citations
7. GTDB-Tk: a toolkit to classify genomes with the Genome Taxonomy Database
   Pierre-Alain Chaumeil, Aaron James Mussig et al. · 2019 · 5,330 citations
8. ShinyGO: a graphical gene-set enrichment tool for animals and plants
   Xijin Ge, Dongmin Jung et al. · 2019 · 5,260 citations · Free PDF
9. The Microbiota-Gut-Brain Axis
   John F. Cryan, Kenneth J. O’Riordan et al. · 2019 · 5,166 citations
10. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis
    Zefang Tang, Boxi Kang et al. · 2019 · 5,105 citations
11. g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)
    Uku Raudvere, Liis Kolberg et al. · 2019 · 5,070 citations
12. Breast Cancer Treatment
    Adrienne Gropper Waks, Eric P. Winer · 2019 · 4,818 citations
13. BEAST 2.5: An advanced software platform for Bayesian evolutionary analysis
    Remco Bouckaert, Timothy G. Vaughan et al. · 2019 · 4,585 citations · Free PDF
14. Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression
    Christoph Hafemeister, Rahul Satija · 2019 · 4,523 citations · Free PDF
15. RAxML-NG: a fast, scalable and user-friendly tool for maximum likelihood phylogenetic inference
    Alexey M. Kozlov, Diego Darriba et al. · 2019 · 4,330 citations · Free PDF
16. In silico analysis enabling informed design for genome editing in medicinal cannabis; gene families and variant characterisation
    Calamita, Elisa, Schmid, Martin et al. · 2019 · 4,224 citations
17. PhyloSuite: An integrated and scalable desktop platform for streamlined molecular sequence data management and evolutionary phylogenetics studies
    Dong Zhang, Fangluan Gao et al. · 2019 · 4,081 citations · Free PDF
18. MetaBAT 2: an adaptive binning algorithm for robust and efficient genome reconstruction from metagenome assemblies
    Dongwan Kang, Feng Li et al. · 2019 · 3,797 citations · Free PDF
19. Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases
    Daniela Parada Venegas, Marjorie K. De la Fuente et al. · 2019 · 3,795 citations · Free PDF
20. The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
    Nathan Kelley, Devon Jeltema et al. · 2019 · 3,518 citations · Free PDF
21. What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases
    Emanuele Rinninella, Pauline Celine Raoul et al. · 2019 · 3,440 citations · Free PDF
22. TYGS is an automated high-throughput platform for state-of-the-art genome-based taxonomy
    Jan P. Meier‐Kolthoff, Markus Göker · 2019 · 3,290 citations · Free PDF
23. miRDB: an online database for prediction of functional microRNA targets
    Yuhao Chen, Xiaowei Wang · 2019 · 3,287 citations
24. Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis
    Laura M. Doyle, Michael Zhuo Wang · 2019 · 3,248 citations · Free PDF
25. CARD 2020: antibiotic resistome surveillance with the comprehensive antibiotic resistance database
    Brian P. Alcock, Amogelang R. Raphenya et al. · 2019 · 3,231 citations

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