Most-cited Genetics and Biochemistry papers of 2021, with free PDFs

The 25 most-cited Genetics and Biochemistry research papers published in 2021, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. Highly accurate protein structure prediction with AlphaFold
   John Jumper, Richard Evans et al. · 2021 · 43,926 citations · Free PDF
2. MEGA11: Molecular Evolutionary Genetics Analysis Version 11
   Koichiro Tamura, Glen Stecher et al. · 2021 · 22,559 citations
3. Twelve years of SAMtools and BCFtools
   Petr Danecek, James Bonfield et al. · 2021 · 15,657 citations · Free PDF
4. Integrated analysis of multimodal single-cell data
   Yuhan Hao, Stephanie Hao et al. · 2021 · 15,483 citations · Free PDF
5. clusterProfiler 4.0: A universal enrichment tool for interpreting omics data
   Tianzhi Wu, Erqiang Hu et al. · 2021 · 12,466 citations · Free PDF
6. Interactive Tree Of Life (iTOL) v5: an online tool for phylogenetic tree display and annotation
   Ivica Letunić, Peer Bork B · 2021 · 11,300 citations
7. Inference and analysis of cell-cell communication using CellChat
   Suoqin Jin, Christian Fernando Guerrero‐Juarez et al. · 2021 · 8,279 citations · Free PDF
8. AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models
   Mihály Váradi, Stephen Anyango et al. · 2021 · 7,899 citations
9. BUSCO Update: Novel and Streamlined Workflows along with Broader and Deeper Phylogenetic Coverage for Scoring of Eukaryotic, Prokaryotic, and Viral Genomes
   Mosè Manni, Matthew Berkeley et al. · 2021 · 6,159 citations · Free PDF
10. Accurate prediction of protein structures and interactions using a three-track neural network
    Minkyung Baek, Frank DiMaio et al. · 2021 · 5,536 citations · Free PDF
11. eggNOG-mapper v2: Functional Annotation, Orthology Assignments, and Domain Prediction at the Metagenomic Scale
    Carlos P. Cantalapiedra, Ana Hernández-Plaza et al. · 2021 · 5,328 citations · Free PDF
12. Sensitive protein alignments at tree-of-life scale using DIAMOND
    Benjamin Buchfink, Klaus Reuter et al. · 2021 · 5,093 citations · Free PDF
13. MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights
    Zhiqiang Pang, Jasmine Chong et al. · 2021 · 3,997 citations
14. Gene Set Knowledge Discovery with Enrichr
    Zhuorui Xie, Allison Bailey et al. · 2021 · 3,561 citations
15. Towards complete and error-free genome assemblies of all vertebrate species
    Arang Rhie, Shane McCarthy et al. · 2021 · 3,153 citations · Free PDF
16. Biological structure and function emerge from scaling unsupervised learning to 250 million protein sequences
    Alexander W. Rives, Joshua Meier et al. · 2021 · 3,123 citations · Free PDF
17. Highly accurate protein structure prediction for the human proteome
    Kathryn Tunyasuvunakool, Jonas Adler et al. · 2021 · 3,047 citations · Free PDF
18. Database resources of the national center for biotechnology information
    Eric W Sayers, Evan Bolton et al. · 2021 · 2,825 citations
19. The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies
    Celia Andrés, José Manuel Pérez de la Lastra et al. · 2021 · 2,784 citations · Free PDF
20. Multivariable association discovery in population-scale meta-omics studies
    Himel Mallick, Ali Rahnavard et al. · 2021 · 2,601 citations · Free PDF
21. Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
    Urmo Võsa, Annique Claringbould et al. · 2021 · 2,580 citations · Free PDF
22. HMDB 5.0: the Human Metabolome Database for 2022
    David Scott Wishart, AnChi Guo et al. · 2021 · 2,537 citations
23. The carbohydrate-active enzyme database: functions and literature
    Élodie Drula, Marie-Line Garron et al. · 2021 · 2,475 citations
24. GTDB: an ongoing census of bacterial and archaeal diversity through a phylogenetically consistent, rank normalized and complete genome-based taxonomy
    Donovan H. Parks, Maria S. Chuvochina et al. · 2021 · 2,412 citations
25. The reactome pathway knowledgebase 2022
    Marc E. Gillespie, Bijay Jassal et al. · 2021 · 2,361 citations

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