“Sensitive protein alignments at tree-of-life scale using DIAMOND” (2021), by Benjamin Buchfink et al. Genetics and Biochemistry research paper. Original abstract below, unchanged. A free PDF is available.

Sensitive protein alignments at tree-of-life scale using DIAMOND

Benjamin Buchfink, Klaus Reuter, Hajk‐Georg Drost · April 1, 2021 · Genetics and Biochemistry

Abstract

We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.

Free PDF DOI: 10.1038/s41592-021-01101-x