Most-cited Genetics and Biochemistry papers of 2016, with free PDFs

The 25 most-cited Genetics and Biochemistry research papers published in 2016, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets
   Sudhir Kumar, Glen Stecher et al. · 2016 · 44,250 citations
2. Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
   Maxim V. Kuleshov, Matthew R. Jones et al. · 2016 · 10,867 citations
3. VSEARCH: a versatile open source tool for metagenomics
   Torbjørn Rognes, Tomáš Flouri et al. · 2016 · 10,810 citations
4. MultiQC: summarize analysis results for multiple tools and samples in a single report
   Philip Ewels, Måns Magnusson et al. · 2016 · 10,196 citations
5. Complex heatmaps reveal patterns and correlations in multidimensional genomic data
   Zuguang Gu, Roland Eils et al. · 2016 · 10,174 citations
6. Analysis of protein-coding genetic variation in 60,706 humans
   Monkol Lek, Konrad J. Karczewski et al. · 2016 · 9,662 citations · Free PDF
7. Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator
   Jack Bowden, George Davey Smith et al. · 2016 · 8,991 citations · Free PDF
8. KEGG: new perspectives on genomes, pathways, diseases and drugs
   Minoru I. Kanehisa, Miho Furumichi et al. · 2016 · 8,900 citations
9. deepTools2: a next generation web server for deep-sequencing data analysis
   Fidel Ramírez, Devon Patrick Ryan et al. · 2016 · 8,214 citations · Free PDF
10. The Ensembl Variant Effect Predictor
    William M. McLaren, Laurent Gil et al. · 2016 · 8,173 citations · Free PDF
11. Introducing EzBioCloud: a taxonomically united database of 16S rRNA gene sequences and whole-genome assemblies
    Seok-Hwan Yoon, Sung Min Ha et al. · 2016 · 7,742 citations
12. NCBI prokaryotic genome annotation pipeline
    Tatiana A. Tatusova, Michael N. DiCuccio et al. · 2016 · 7,052 citations
13. The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible
    Damian Szklarczyk, John H. Morris et al. · 2016 · 7,024 citations · Free PDF
14. W-IQ-TREE: a fast online phylogenetic tool for maximum likelihood analysis
    Jana Trifinopoulos, Lam-Tung Nguyen et al. · 2016 · 5,539 citations
15. The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses
    Gil Stelzer, Naomi Rosen et al. · 2016 · 5,503 citations
16. Revised Estimates for the Number of Human and Bacteria Cells in the Body
    Ron Sender, Shai Fuchs et al. · 2016 · 5,423 citations · Free PDF
17. PartitionFinder 2: New Methods for Selecting Partitioned Models of Evolution for Molecular and Morphological Phylogenetic Analyses
    Robert Lanfear, Paul B. Frandsen et al. · 2016 · 5,282 citations
18. Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees
    Ivica Letunić, Peer Bork B · 2016 · 5,044 citations
19. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
    Itay Tirosh, Benjamin Izar et al. · 2016 · 4,949 citations
20. ggtree : an r package for visualization and annotation of phylogenetic trees with their covariates and other associated data
    Guangchuang Yu, David Keith Smith et al. · 2016 · 4,888 citations
21. Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
    Mingxun Wang, Jeremy Carver et al. · 2016 · 4,611 citations · Free PDF
22. UniProt: the universal protein knowledgebase
    The UniProt Consortium · 2016 · 4,463 citations
23. Ki67 expression in breast cancer
    Mohamed A. Elkablawy, Abdulkader Mohammed Albasri et al. · 2016 · 4,384 citations
24. Comparative Protein Structure Modeling Using MODELLER
    Benjamin Webb, Andrej Šali · 2016 · 4,350 citations
25. Dietary Advanced Glycation End Products and Their Potential Role in Cardiometabolic Disease in Children
    Anshu Gupta, Jaime Uribarri · 2016 · 4,011 citations

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