Most-cited Genetics and Biochemistry papers of 2024, with free PDFs

The 25 most-cited Genetics and Biochemistry research papers published in 2024, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. Accurate structure prediction of biomolecular interactions with AlphaFold 3
   Josh Abramson, Jonas Adler et al. · 2024 · 15,544 citations
2. Interactive Tree of Life (iTOL) v6: recent updates to the phylogenetic tree display and annotation tool
   Ivica Letunić, Peer Bork B · 2024 · 4,529 citations
3. Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
   Joshua A Welsh, Deborah C. I. Goberdhan et al. · 2024 · 4,446 citations · Free PDF
4. KEGG: biological systems database as a model of the real world
   Minoru I. Kanehisa, Miho Furumichi et al. · 2024 · 2,539 citations
5. UniProt: the Universal Protein Knowledgebase in 2025
   Alex G. Bateman, Maria Jesus Martin et al. · 2024 · 2,434 citations
6. MEGA12: Molecular Evolutionary Genetic Analysis Version 12 for Adaptive and Green Computing
   Sudhir Kumar, Glen Stecher et al. · 2024 · 2,378 citations · Free PDF
7. MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation
   Zhiqiang Pang, Yao Ping Lu et al. · 2024 · 2,303 citations
8. NF-κB in biology and targeted therapy: new insights and translational implications
   Qing Guo, Yizi Jin et al. · 2024 · 2,039 citations · Free PDF
9. PubChem 2025 update
   Sunghwan Kim, Jie Chen et al. · 2024 · 1,357 citations
10. Extracellular vesicles as tools and targets in therapy for diseases
    Mudasir A. Kumar, Sadaf Khursheed Baba et al. · 2024 · 1,336 citations · Free PDF
11. Infectious Diseases Society of America 2024 Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections
    Pranita D. Tamma, Emily L. Heil et al. · 2024 · 1,178 citations
12. Mitochondrial dysfunction: mechanisms and advances in therapy
    Zong Yao, Hao Li et al. · 2024 · 1,174 citations
13. TGF-β signaling in health, disease and therapeutics
    Ziqin Deng, Tao T. Fan et al. · 2024 · 1,164 citations · Free PDF
14. Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
    Jian Sheng Loh, Wen Qi Mak et al. · 2024 · 1,148 citations · Free PDF
15. InterPro: the protein sequence classification resource in 2025
    Matthias Blum, Antonina E. Andreeva et al. · 2024 · 1,069 citations · Free PDF
16. Cell death
    Kim Newton, Andreas Strasser et al. · 2024 · 991 citations
17. Generalized biomolecular modeling and design with RoseTTAFold All-Atom
    Rohith Krishna, Jue Wang et al. · 2024 · 948 citations · Free PDF
18. Genomic data in the All of Us Research Program
    Manuscript Writing Group, Alexander G. Bick et al. · 2024 · 831 citations · Free PDF
19. Adeno-associated virus as a delivery vector for gene therapy of human diseases
    Jiang-Hui Wang, Dominic J. Gessler et al. · 2024 · 829 citations · Free PDF
20. Tumor biomarkers for diagnosis, prognosis and targeted therapy
    Yue Zhou, Lei Tao et al. · 2024 · 722 citations
21. Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
    Meng Zhang, Qian Liu et al. · 2024 · 709 citations
22. Liquid biopsy in cancer: current status, challenges and future prospects
    Liwei Ma, Huiling Guo et al. · 2024 · 708 citations · Free PDF
23. Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution
    Yuhang Hong, Alessandra Boiti et al. · 2024 · 695 citations · Free PDF
24. Clinical applications of stem cell-derived exosomes
    Fei Tan, Xuran Li et al. · 2024 · 694 citations · Free PDF
25. Automated model building and protein identification in cryo-EM maps
    Kiarash Jamali, Lukas Käll et al. · 2024 · 686 citations · Free PDF

2016 2017 2018 2019 2020 2021 2022 2023 2025

New Genetics and Biochemistry papers