Most-cited Genetics and Biochemistry papers of 2025, with free PDFs

The 25 most-cited Genetics and Biochemistry research papers published in 2025, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. Breast cancer: pathogenesis and treatments
   Xin Xiong, Lewei Zheng et al. · 2025 · 949 citations · Free PDF
2. Simulating 500 million years of evolution with a language model
   Thomas Hayes, Roshan Rao et al. · 2025 · 916 citations
3. edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets
   Yunshun Chen, Lizhong Chen et al. · 2025 · 821 citations · Free PDF
4. Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances
   Xiaojun Xu, Yan Pang et al. · 2025 · 790 citations · Free PDF
5. CoverM: read alignment statistics for metagenomics
   Samuel T. N. Aroney, Rhys J P Newell et al. · 2025 · 513 citations · Free PDF
6. NF-κB in inflammation and cancer
   Hongmei Mao, Xiaocui Zhao et al. · 2025 · 486 citations · Free PDF
7. The intestinal barrier: a pivotal role in health, inflammation, and cancer
   Markus F. Neurath, David Artis et al. · 2025 · 484 citations
8. Lactate and lactylation in cancer
   Jie Chen, Ziyue Huang et al. · 2025 · 470 citations · Free PDF
9. Cellpose3: one-click image restoration for improved cellular segmentation
   Carsen Stringer, Marius Pachitariu · 2025 · 464 citations · Free PDF
10. Global evolution of inflammatory bowel disease across epidemiologic stages
    Lindsay Hracs, Joseph W. Windsor et al. · 2025 · 454 citations · Free PDF
11. Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines
    Wen‐Jing Xiao, Wenjie Jiang et al. · 2025 · 411 citations
12. Energy metabolism in health and diseases
    Hui Liu, Shuo Wang et al. · 2025 · 396 citations
13. The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy
    Meike Vogler, Yannick Braun et al. · 2025 · 387 citations · Free PDF
14. Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease
    Kiran Musunuru, Sarah A. Grandinette et al. · 2025 · 367 citations
15. Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives
    Chunsik Lee, Myung‐Jin Kim et al. · 2025 · 357 citations
16. Oxidative Stress: Signaling Pathways, Biological Functions, and Disease
    Sixuan Liu, Jiachen Liu et al. · 2025 · 355 citations
17. Scalable emulation of protein equilibrium ensembles with generative deep learning
    Sarah Lewis, Tim Hempel et al. · 2025 · 335 citations
18. The gut microbiota-immune-brain axis: Therapeutic implications
    Kenneth J. O’Riordan, Gerard M. Moloney et al. · 2025 · 318 citations
19. Redox regulation: mechanisms, biology and therapeutic targets in diseases
    Bowen Li, Hui Ming et al. · 2025 · 313 citations
20. Segment Anything for Microscopy
    Anwai Archit, Luca Freckmann et al. · 2025 · 306 citations · Free PDF
21. Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy
    Yao Shen, Nairui Fan et al. · 2025 · 299 citations
22. High-definition spatial transcriptomic profiling of immune cell populations in colorectal cancer
    Michelli F. Oliveira, Juan P. Romero et al. · 2025 · 298 citations
23. NLRP3 inflammasome in neuroinflammation and central nervous system diseases
    Wen Rong Xu, Yi Huang et al. · 2025 · 295 citations
24. MIQE 2.0: Revision of the Minimum Information for Publication of Quantitative Real-Time PCR Experiments Guidelines
    Stephen Andrew Bustin, Jan M. Ruijter et al. · 2025 · 286 citations
25. Atomic context-conditioned protein sequence design using LigandMPNN
    Justas Dauparas, Gyu Rie Lee et al. · 2025 · 282 citations · Free PDF

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