“Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities” (2022), by Jiaqi Liu et al. Genetics and Biochemistry research paper. Original abstract below, unchanged. A free PDF is available.

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

Jiaqi Liu, Qing Xiao, Jiani Xiao et al. · January 3, 2022 · Genetics and Biochemistry

Abstract

The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment.

Free PDF DOI: 10.1038/s41392-021-00762-6