Most-cited Medicine papers of 2018, with free PDFs

The 25 most-cited Medicine research papers published in 2018, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
   Freddie Bray, Jacques Ferlay et al. · 2018 · 84,371 citations
2. Cancer statistics, 2018
   Rebecca L. Siegel, Kimberly D. Miller et al. · 2018 · 16,596 citations
3. Sarcopenia: revised European consensus on definition and diagnosis
   Alfonso José Cruz-Jentoft, Gülistan Bahat et al. · 2018 · 13,852 citations
4. International Diabetes Federation 2017
   Ann M. Carracher, Payal H. Marathe et al. · 2018 · 13,442 citations
5. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition
   2018 · 10,749 citations
6. NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease
   Clifford R. Jack, David Alan Bennett et al. · 2018 · 10,498 citations
7. 2018 ESC/ESH Guidelines for the management of arterial hypertension
   Bryan Williams, Giuseppe Mancia et al. · 2018 · 10,326 citations · Free PDF
8. The Physical Activity Guidelines for Americans
   Katrina L. Piercy, Richard P. Troiano et al. · 2018 · 9,634 citations
9. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods
   Jacques Ferlay, Murielle Colombet et al. · 2018 · 7,583 citations
10. 2018 ESC/EACTS Guidelines on myocardial revascularization
    Franz‐Josef Neumann, Miguel Sousa‐Uva et al. · 2018 · 7,165 citations
11. Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association
    Emelia J. Benjamin, Salim S. Virani et al. · 2018 · 7,132 citations
12. Cancer immunotherapy using checkpoint blockade
    Antoni Ribas, Jedd D. Wolchok · 2018 · 6,731 citations
13. Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer
    Leena Gandhi, Delvys Rodríguez‐Abreu et al. · 2018 · 6,605 citations
14. Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes
    Stephen D. Wiviott, Itamar Raz et al. · 2018 · 6,368 citations
15. Fourth universal definition of myocardial infarction (2018)
    Kristian A. Thygesen, Joseph S. Alpert et al. · 2018 · 5,888 citations
16. The Immune Landscape of Cancer
    Vésteinn Thórsson, Vésteinn Thorsson et al. · 2018 · 5,774 citations · Free PDF
17. Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia
    Shannon L. Maude, Theodore Willis Laetsch et al. · 2018 · 5,694 citations
18. Origin and evolution of pathogenic coronaviruses
    Jie Cui, Fang Li et al. · 2018 · 5,564 citations · Free PDF
19. Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
    Jeffrey D Stanaway, Ashkan Afshin et al. · 2018 · 4,948 citations · Free PDF
20. Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging
    Gregory W. Albers, Michael P. Marks et al. · 2018 · 4,940 citations
21. Immune-Related Adverse Events Associated with Immune Checkpoint Blockade
    Michael Andrew Postow, Robert Sidlow et al. · 2018 · 4,822 citations
22. Convolutional neural networks: an overview and application in radiology
    Rikiya Yamashita, Mizuho Nishio et al. · 2018 · 4,682 citations · Free PDF
23. Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma
    Robert John Motzer, Nizar M. Tannir et al. · 2018 · 4,649 citations · Free PDF
24. Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases
    Jorge A. Marrero, Laura Kulik et al. · 2018 · 4,552 citations
25. Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance
    Norah A. Terrault, Anna Suk-Fong Lok et al. · 2018 · 4,296 citations

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