Most-cited Medicine papers of 2016, with free PDFs

The 25 most-cited Medicine research papers published in 2016, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer
   Andreas Daniel Hartkopf, Florin‐Andrei Taran et al. · 2016 · 30,856 citations
2. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
   Mervyn Singer, Clifford Scott Deutschman et al. · 2016 · 28,103 citations
3. Cancer statistics in China, 2015
   Wanqing Chen, Rongshou Zheng et al. · 2016 · 17,125 citations
4. Cancer statistics, 2016
   Rebecca L. Siegel, Kimberly D. Miller et al. · 2016 · 16,018 citations
5. Ultrastructural Characterization of the Lower Motor System in a Mouse Model of Krabbe Disease
   Valentina Cappello, Laura Marchetti et al. · 2016 · 13,107 citations · Free PDF
6. Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease?
   Aimun Ahmed, Tom Jorna et al. · 2016 · 11,725 citations
7. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
   Piotr Ponikowski, Adriaan A Voors et al. · 2016 · 11,449 citations
8. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia
   Daniel A. Arber, Attilio Orazi et al. · 2016 · 10,138 citations
9. Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer
   Martin Reck, Delvys Rodríguez‐Abreu et al. · 2016 · 10,102 citations · Free PDF
10. The 2016 revision of the World Health Organization classification of lymphoid neoplasms
    Steven H. Swerdlow, Elı́as Campo et al. · 2016 · 7,837 citations
11. Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs
    Varun Gulshan, Lily H. Peng et al. · 2016 · 7,718 citations
12. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
    Mohammad Hossein Forouzanfar, Ashkan Afshin et al. · 2016 · 7,715 citations · Free PDF
13. Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
    Steven P. Marso, Gilbert H. Daniels et al. · 2016 · 7,592 citations · Free PDF
14. Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
    Jazli Aziz, Hafiz Shezali et al. · 2016 · 7,298 citations
15. Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
    Steven P. Marso, Stephen Charles Bain et al. · 2016 · 6,852 citations
16. Changes of Intestinal Functions in Liver Cirrhosis
    Hiroshi Fukui, Reiner Wiest · 2016 · 6,810 citations
17. 2016 European Guidelines on cardiovascular disease prevention in clinical practice
    Massimo Francesco Piepoli, Arno Wilhelmus Hoes et al. · 2016 · 6,471 citations
18. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
    Paulus F. Kirchhof, Stefano Benussi et al. · 2016 · 6,448 citations · Free PDF
19. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
    Paulus F. Kirchhof, Stefano Benussi et al. · 2016 · 6,435 citations
20. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-years for 32 Cancer Groups, 1990 to 2015
    Christina Fitzmaurice, Christine Allen et al. · 2016 · 6,229 citations · Free PDF
21. The amyloid hypothesis of Alzheimer's disease at 25 years
    Dennis J. Selkoe, John Hardy · 2016 · 6,154 citations
22. Cancer treatment and survivorship statistics, 2016
    Kimberly D. Miller, Rebecca L. Siegel et al. · 2016 · 6,077 citations
23. 2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
    Piotr P. Ponikowski, Adriaan A. Voors et al. · 2016 · 5,880 citations
24. Natural Products as Sources of New Drugs from 1981 to 2014
    David J. Newman, Gordon M. L. Cragg · 2016 · 5,861 citations
25. Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel
    Hartmut Döhner, Elihu H. Estey et al. · 2016 · 5,797 citations

2017 2018 2019 2020 2021 2022 2023 2024 2025

New Medicine papers