Most-cited Medicine papers of 2017, with free PDFs

The 25 most-cited Medicine research papers published in 2017, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review
   Rimda Wanchoo, Sabine Karam et al. · 2017 · 15,262 citations
2. Cancer statistics, 2017
   Rebecca L. Siegel, Kimberly D. Miller et al. · 2017 · 14,732 citations
3. Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice
   Yi Chen, Lei Wang et al. · 2017 · 10,686 citations
4. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation
   Borja Ibáñez, Stefan Karl James et al. · 2017 · 9,744 citations
5. The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function
   Gijs H. Goossens · 2017 · 8,483 citations
6. Health Effects of Overweight and Obesity in 195 Countries over 25 Years
   The GBD 2015 Obesity Collaborators · 2017 · 7,904 citations
7. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
   Bruce Charles Neal, Vlado Perkovic et al. · 2017 · 7,822 citations · Free PDF
8. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults
   Leandra Abarca-Gómez, Ziad Abdeen et al. · 2017 · 7,503 citations · Free PDF
9. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
   Paul Kieran Whelton, Robert M. Carey et al. · 2017 · 7,384 citations
10. The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
    Naga Chalasani, Zobair M. Younossi et al. · 2017 · 7,234 citations
11. An Overview of Heart Rate Variability Metrics and Norms
    Fred Shaffer, Jay P. Ginsberg · 2017 · 7,145 citations · Free PDF
12. Intravenous Fluids and Acute Kidney Injury
    Xiaoqiang Ding, Zhen Cheng et al. · 2017 · 6,831 citations
13. Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
    Dung Thi Le, Jennifer N. Durham et al. · 2017 · 6,616 citations
14. Computational Radiomics System to Decode the Radiographic Phenotype
    Joost J. M. van Griethuysen, Andriy Fedorov et al. · 2017 · 6,551 citations
15. The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population‐based to a more “personalized” approach to cancer staging
    Mahul B. Amin, Frederick L. Greene et al. · 2017 · 6,521 citations
16. 2017 ESC/EACTS Guidelines for the management of valvular heart disease
    Helmut Baumgartner, Volkmar Falk et al. · 2017 · 6,256 citations · Free PDF
17. Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease
    Marc Steven Sabatine, Robert Patrick Giugliano et al. · 2017 · 6,131 citations
18. Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
    Sattva Swarup Neelapu, Frederick Lundry Locke et al. · 2017 · 6,000 citations
19. TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells
    Taiwen Li, Jing‐Yu Fan et al. · 2017 · 5,950 citations
20. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct
    Raul G. Nogueira, Ashutosh Prabhakar Jadhav et al. · 2017 · 5,638 citations
21. Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
    Bertrand Routy, Emmanuelle Le Chatelier et al. · 2017 · 5,622 citations
22. Osimertinib in Untreated EGFR -Mutated Advanced Non–Small-Cell Lung Cancer
    Jean‐Charles Soria, Yuichiro Ohe et al. · 2017 · 5,384 citations
23. Acute Abdomen: A Rare Case of Ruptured Hepatocellular Carcinoma
    Severin Gloor, Kai Oliver Jensen et al. · 2017 · 5,371 citations
24. Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
    Jedd D. Wolchok, Vanna Chiarion‐Sileni et al. · 2017 · 5,348 citations
25. Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury
    Changmeng Cui, Jianzhong Cui et al. · 2017 · 5,203 citations

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New Medicine papers