Most-cited Medicine papers of 2021, with free PDFs

The 25 most-cited Medicine research papers published in 2021, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
   Hyuna Sung, Adalberto M. Filho et al. · 2021 · 108,758 citations
2. Cancer Statistics, 2021
   Rebecca L. Siegel, Kimberly D. Miller et al. · 2021 · 16,557 citations
3. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
   Theresa A. McDonagh, Marco Metra et al. · 2021 · 13,381 citations · Free PDF
4. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary
   David N. Louis, Arie Perry et al. · 2021 · 12,163 citations
5. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
   Frank L.J. Visseren, François Mach et al. · 2021 · 6,509 citations
6. Heart Disease and Stroke Statistics—2021 Update
   Salim S. Virani, Álvaro Alonso et al. · 2021 · 5,783 citations
7. Cancer statistics for the year 2020: An overview
   Jacques Ferlay, Murielle Colombet et al. · 2021 · 5,723 citations
8. 2021 ESC/EACTS Guidelines for the management of valvular heart disease
   Alec S. Vahanian, Friedhelm Beyersdorf et al. · 2021 · 5,653 citations
9. Natural products in drug discovery: advances and opportunities
   Atanas G. Atanasov, Sergey B. Zotchev et al. · 2021 · 5,405 citations · Free PDF
10. Once-Weekly Semaglutide in Adults with Overweight or Obesity
    John P.H. Wilding, Rachel Louise Batterham et al. · 2021 · 5,089 citations · Free PDF
11. Plasma Hsp90 levels in patients with systemic sclerosis and relation to lung and skin involvement: a cross-sectional and longitudinal study
    Hana Štorkánová, Sabína Oreská et al. · 2021 · 5,038 citations · Free PDF
12. Empagliflozin in Heart Failure with a Preserved Ejection Fraction
    Stefan D. Anker, Javed Butler et al. · 2021 · 4,828 citations
13. 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2022
    2021 · 4,706 citations
14. New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race
    Lesley A. Inker, Nwamaka D. Eneanya et al. · 2021 · 4,501 citations
15. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants
    Bin Zhou, Rodrigo Martin Carrillo-Larco et al. · 2021 · 3,868 citations · Free PDF
16. Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association
    Tiffany M. Powell‐Wiley, Paul Poirier et al. · 2021 · 3,657 citations
17. 2021 Guideline for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack: A Guideline From the American Heart Association/American Stroke Association
    Dawn Kleindorfer, Amytis Towfighi et al. · 2021 · 3,182 citations
18. Functional Hydrogels as Wound Dressing to Enhance Wound Healing
    Yongping Liang, Jiahui He et al. · 2021 · 3,124 citations
19. Defining Training and Performance Caliber: A Participant Classification Framework
    Alannah K.A. McKay, Trent Stellingwerff et al. · 2021 · 3,022 citations
20. Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant
    Jamie Lopez Bernal, Nick J Andrews et al. · 2021 · 2,926 citations
21. CAR-T cell therapy: current limitations and potential strategies
    Robert C. Sterner, Rosalie M. Sterner et al. · 2021 · 2,895 citations · Free PDF
22. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021
    Laura Evans, Andrew Rhodes et al. · 2021 · 2,895 citations
23. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact
    Hannah Davis, Gina Assaf et al. · 2021 · 2,891 citations · Free PDF
24. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020
    Wei Cao, Hongda Chen et al. · 2021 · 2,884 citations
25. Lutetium-177–PSMA-617 for Metastatic Castration-Resistant Prostate Cancer
    Oliver A. Sartor, Johann Sebastian De Bono et al. · 2021 · 2,823 citations

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