Most-cited Medicine papers of 2022, with free PDFs

The 25 most-cited Medicine research papers published in 2022, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. Cancer statistics, 2022
   Rebecca L. Siegel, Kimberly D. Miller et al. · 2022 · 17,229 citations
2. Hallmarks of Cancer: New Dimensions
   Douglas Hanahan · 2022 · 9,565 citations
3. Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association
   Connie W. Tsao, Aaron W. Aday et al. · 2022 · 5,977 citations
4. Lecanemab in Early Alzheimer’s Disease
   Christopher H. van Dyck, Chad J. Swanson et al. · 2022 · 5,580 citations
5. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019
   Emma L. Nichols, Jaimie D Steinmetz et al. · 2022 · 5,502 citations · Free PDF
6. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms
   Joseph David Khoury, Éric Solary et al. · 2022 · 4,215 citations · Free PDF
7. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms
   Rita Alaggio, Catalina Amador et al. · 2022 · 4,008 citations · Free PDF
8. Tirzepatide Once Weekly for the Treatment of Obesity
   Ania M. Jastreboff, Louis J. Aronne et al. · 2022 · 3,716 citations
9. Cancer treatment and survivorship statistics, 2022
   Kimberly D. Miller, Letícia Nogueira et al. · 2022 · 3,628 citations
10. Cancer statistics in China and United States, 2022: profiles, trends, and determinants
    Changfa Xia, Xuesi Dong et al. · 2022 · 3,419 citations
11. Current and future burden of breast cancer: Global statistics for 2020 and 2040
    Melina Arnold, Eileen Morgan et al. · 2022 · 3,375 citations
12. Global burden of heart failure: a comprehensive and updated review of epidemiology
    Gianluigi Savarese, Peter Moritz Becher et al. · 2022 · 3,317 citations
13. Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN
    Hartmut Döhner, Andrew H. Wei et al. · 2022 · 3,275 citations
14. Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
    Brent R. Stockwell · 2022 · 3,068 citations
15. World Stroke Organization (WSO): Global Stroke Fact Sheet 2022
    Valery L. Feigin, Michael Brainin et al. · 2022 · 2,983 citations
16. Mapping genomic loci implicates genes and synaptic biology in schizophrenia
    Vassily Trubetskoy, Antonio F. Pardiñas et al. · 2022 · 2,960 citations · Free PDF
17. International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data
    Daniel A. Arber, Attilio Orazi et al. · 2022 · 2,893 citations
18. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction
    Scott David Solomon, John J.V. McMurray et al. · 2022 · 2,849 citations · Free PDF
19. Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline
    Ganesh Raghu, Martine Remy-Jardin et al. · 2022 · 2,829 citations
20. Life’s Essential 8: Updating and Enhancing the American Heart Association’s Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association
    Donald M. Lloyd‐Jones, Norrina B. Allen et al. · 2022 · 2,734 citations · Free PDF
21. Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer
    Shanu Modi, William Jacot et al. · 2022 · 2,667 citations
22. Empagliflozin in Patients with Chronic Kidney Disease
    The EMPA-KIDNEY Collaborative Group · 2022 · 2,665 citations
23. New insights into the genetic etiology of Alzheimer’s disease and related dementias
    Céline Bellenguez, Fahri Küçükali et al. · 2022 · 2,500 citations · Free PDF
24. 2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes—2023
    Nuha A. ElSayed, Grazia Aleppo et al. · 2022 · 2,438 citations
25. Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN
    Eileen Morgan, Melina Arnold et al. · 2022 · 2,385 citations

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