Most-cited Medicine papers of 2019, with free PDFs

The 25 most-cited Medicine research papers published in 2019, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. Cancer statistics, 2019
   Rebecca L. Siegel, Kimberly D. Miller et al. · 2019 · 20,202 citations
2. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
   François Mach, Colin Baigent et al. · 2019 · 9,006 citations
3. Integrated genomic analyses of ovarian carcinoma
   Perou, Charles · 2019 · 7,951 citations
4. Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association
   William J. Powers, Alejandro A. Rabinstein et al. · 2019 · 7,489 citations
5. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes
   Juhani M. Knuuti, William C. Wijns et al. · 2019 · 7,181 citations
6. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction
   John J.V. McMurray, Scott David Solomon et al. · 2019 · 7,100 citations
7. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
   Scott M. Grundy, Neil J. Stone et al. · 2019 · 6,192 citations
8. Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
   Vlado Perkovic, Meg Jardine et al. · 2019 · 6,148 citations
9. Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
   Ashkan Afshin, Patrick John Sur et al. · 2019 · 5,791 citations · Free PDF
10. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS)
    Stavros Konstantinides, Guy Meyer et al. · 2019 · 4,932 citations · Free PDF
11. Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients
    Michael J. Mack, Martin B. Leon et al. · 2019 · 4,857 citations
12. 2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk
    François Mach, Colin Baigent et al. · 2019 · 4,856 citations · Free PDF
13. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD
    Francesco Cosentino, Peter J Grant et al. · 2019 · 4,784 citations
14. 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
    Donna K. Arnett, Roger Scott Blumenthal et al. · 2019 · 4,505 citations
15. Hepatocellular Carcinoma
    Augusto Villanueva · 2019 · 4,476 citations
16. Machine Learning in Medicine
    Alvin Rajkomar, Jay B. Dean et al. · 2019 · 4,428 citations
17. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis
    Adam Benjafield, Najib Ayas et al. · 2019 · 4,286 citations · Free PDF
18. Cancer treatment and survivorship statistics, 2019
    Kimberly D. Miller, Letícia Nogueira et al. · 2019 · 4,244 citations
19. Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement
    Brian L. Graham, Irene Steenbruggen et al. · 2019 · 4,241 citations
20. Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis
    Marc Arbyn, Elisabete Weiderpass et al. · 2019 · 4,124 citations
21. Global trends in insufficient physical activity among adolescents: a pooled analysis of 298 population-based surveys with 1·6 million participants
    Regina Guthold, Gretchen A Stevens et al. · 2019 · 3,995 citations
22. Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range
    Tadej Battelino, Thomas Danne et al. · 2019 · 3,971 citations
23. The potential for artificial intelligence in healthcare
    Thomas H. Davenport, Ravi Kalakota · 2019 · 3,778 citations · Free PDF
24. Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
    James Larkin, Vanna Chiarion‐Sileni et al. · 2019 · 3,712 citations · Free PDF
25. Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients
    Jeffrey J. Popma, G. Michael Deeb et al. · 2019 · 3,681 citations

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