Most-cited Medicine papers of 2025, with free PDFs

The 25 most-cited Medicine research papers published in 2025, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. Cancer statistics, 2025
   Rebecca L. Siegel, Tyler B. Kratzer et al. · 2025 · 3,046 citations
2. Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021
   Marie Ng, Emmanuela E. Gakidou et al. · 2025 · 1,105 citations · Free PDF
3. 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association
   Seth Shay Martin, Aaron W. Aday et al. · 2025 · 1,074 citations
4. 2025 ESC/EACTS Guidelines for the management of valvular heart disease
   Fabien Praz, Michael Andrew Borger et al. · 2025 · 1,050 citations
5. Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis
   Arun Jayant Sanyal, Philip Noel Newsome et al. · 2025 · 1,034 citations
6. Toward expert-level medical question answering with large language models
   Karan Singhal, Tao Tu et al. · 2025 · 967 citations · Free PDF
7. BindingDB Entry 50022536: Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase.
   BindingDB · 2025 · 845 citations
8. 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer
   Matthew David Ringel, Julie Ann Sosa et al. · 2025 · 703 citations
9. antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation
   Kai Blin, Simon Shaw et al. · 2025 · 673 citations · Free PDF
10. Free radicals and their impact on health and antioxidant defenses: a review
    Nisansala Chandimali, Seon Gyeong Bak et al. · 2025 · 664 citations · Free PDF
11. Global, Regional, and National Burden of Cardiovascular Diseases and Risk Factors in 204 Countries and Territories, 1990-2023
    Benjamin A. Stark, Nicole K. DeCleene et al. · 2025 · 662 citations · Free PDF
12. 2025 Focused Update of the 2019 ESC/EAS Guidelines for the management of dyslipidaemias
    François Mach, Konstantinos C. Koskinas et al. · 2025 · 643 citations · Free PDF
13. Projections for prevalence of Parkinson’s disease and its driving factors in 195 countries and territories to 2050: modelling study of Global Burden of Disease Study 2021
    Dongning Su, Yusha Cui et al. · 2025 · 608 citations
14. Tirzepatide as Compared with Semaglutide for the Treatment of Obesity
    Louis J. Aronne, Deborah Bade Horn et al. · 2025 · 598 citations
15. 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
    Sunil V. Rao, Michelle L. O’Donoghue et al. · 2025 · 595 citations
16. Advancements and limitations in traditional anti-cancer therapies: a comprehensive review of surgery, chemotherapy, radiation therapy, and hormonal therapy
    Aasma Zafar, Summaiya Khatoon et al. · 2025 · 558 citations · Free PDF
17. 2025 Alzheimer's disease facts and figures
    2025 · 468 citations
18. Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021
    Jessica A Kerr, George Patton et al. · 2025 · 457 citations · Free PDF
19. 2025 ESC Guidelines for the management of myocarditis and pericarditis
    Jeanette Schulz‐Menger, Valentino Collini et al. · 2025 · 429 citations
20. Updated classification of epileptic seizures: Position paper of the International League Against Epilepsy
    Sándor Beniczky, Eugen Trinka et al. · 2025 · 418 citations · Free PDF
21. Global, regional, and national burden of chronic kidney disease in adults, 1990–2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023
    Patrick Barry Mark, Lauryn K Stafford et al. · 2025 · 411 citations · Free PDF
22. Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM
    Oliver A. Cornely, Rosanne Sprute et al. · 2025 · 408 citations · Free PDF
23. Neoadjuvant and Adjuvant Pembrolizumab in Locally Advanced Head and Neck Cancer
    Ravindra Uppaluri, Robert I. Haddad et al. · 2025 · 406 citations
24. Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes
    Darren K. McGuire, Nikolaus Marx et al. · 2025 · 397 citations
25. IDF Diabetes Atlas 11th edition 2025: global prevalence and projections for 2050
    Bruce Bartholow Duncan, Dianna J. Magliano et al. · 2025 · 396 citations

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