Most-cited Neuroscience papers of 2025, with free PDFs

The 25 most-cited Neuroscience research papers published in 2025, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. Prevalence and Early Identification of Autism Spectrum Disorder Among Children Aged 4 and 8 Years — Autism and Developmental Disabilities Monitoring Network, 16 Sites, United States, 2022
   Kelly A. Shaw, Susan Williams et al. · 2025 · 810 citations · Free PDF
2. Neuroinflammation across neurological diseases
   Fu‐Dong Shi, Voon Wee Yong · 2025 · 271 citations
3. The Role of GABA in the Pathophysiology and Treatment of Anxiety Disorders
   Charles B. Nemeroff, MD et al. · 2025 · 263 citations
4. Mechanisms of GLP-1 Receptor Agonist-Induced Weight Loss: A Review of Central and Peripheral Pathways in Appetite and Energy Regulation
   Areesha Moiz, Kristian B. Filion et al. · 2025 · 228 citations
5. Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s disease
   Robert E. Handsaker, Seva Kashin et al. · 2025 · 206 citations
6. A Meta-analysis of Repetitive Transcranial Magnetic Stimulation in the Treatment of Depression
   Paul E. Holtzheimer, Joan E. Russo et al. · 2025 · 201 citations
7. Chronic Stress-Associated Depressive Disorders: The Impact of HPA Axis Dysregulation and Neuroinflammation on the Hippocampus—A Mini Review
   Ai Ai Lei, Vanessa Wen Xian Phang et al. · 2025 · 199 citations
8. The lab streaming layer for synchronized multimodal recording
   Christian Kothe, Seyed Yahya Shirazi et al. · 2025 · 199 citations · Free PDF
9. A review of deep learning for brain tumor analysis in MRI
   Felix J. Dorfner, Jay B. Patel et al. · 2025 · 193 citations · Free PDF
10. Functional connectomics spanning multiple areas of mouse visual cortex
    J. Alexander Bae, Mahaly Baptiste et al. · 2025 · 193 citations
11. Treatment of Autism Spectrum Disorder in Children and Adolescents
    Melissa DeFilippis, Karen Dineen Wagner · 2025 · 178 citations
12. A brain-wide map of neural activity during complex behaviour
    Leenoy Meshulam, Dora E. Angelaki et al. · 2025 · 177 citations · Free PDF
13. Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression
    Amanda Gollo Bertollo, Camila Ferreira Santos et al. · 2025 · 146 citations · Free PDF
14. From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine
    Corneliu Toader, Matei Șerban et al. · 2025 · 146 citations · Free PDF
15. Neuroinflammation—A Crucial Factor in the Pathophysiology of Depression—A Comprehensive Review
    Andreea Sălcudean, Cristina-Raluca Bodo et al. · 2025 · 144 citations
16. Neural Manifold Decoder for Acupuncture Stimulations With Representation Learning: An Acupuncture-Brain Interface
    Haitao Yu, Fanyi Zeng et al. · 2025 · 142 citations
17. Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease
    Sophia M. Shi, Ryan J. Suh et al. · 2025 · 141 citations
18. The Glutamate/ GABA ‐Glutamine Cycle: Insights, Updates, and Advances
    Jens Velde Andersen · 2025 · 140 citations
19. Bio-inspired electronics: Soft, biohybrid, and “living” neural interfaces
    Dimitris Boufidis, Raghav Garg et al. · 2025 · 137 citations · Free PDF
20. Interaction of the Vagus Nerve and Serotonin in the Gut–Brain Axis
    Young Keun Hwang, Jae Sang Oh · 2025 · 131 citations · Free PDF
21. Microglial activation states and their implications for Alzheimer's Disease
    Zachary Valiukas, Kathy Tangalakis et al. · 2025 · 130 citations
22. Tryptophan Depletion, Serotonin, and Depression: Where Do We Stand?
    Alexander Neumeister · 2025 · 130 citations
23. Advanced Brain Tumor Classification in MR Images Using Transfer Learning and Pre-Trained Deep CNN Models
    Rukiye Disci, Fatih Gürcan et al. · 2025 · 121 citations · Free PDF
24. Breaking the Barrier: The Role of Proinflammatory Cytokines in BBB Dysfunction
    Małgorzata Gryka-Marton, Anna D. Grabowska et al. · 2025 · 118 citations · Free PDF
25. Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an update
    Weilong Wu, Xiao-xi Gong et al. · 2025 · 118 citations · Free PDF

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