Most-cited Neuroscience papers of 2021, with free PDFs

The 25 most-cited Neuroscience research papers published in 2021, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. Perineuronal nets stabilize the grid cell network
   Ane Charlotte Christensen, Kristian Kinden Lensjø et al. · 2021 · 1,866 citations · Free PDF
2. Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2018
   Matthew J. Maenner, Kelly A. Shaw et al. · 2021 · 1,819 citations · Free PDF
3. The role of prefrontal cortex in cognitive control and executive function
   Naomi P. Friedman, Trevor William Robbins · 2021 · 1,732 citations · Free PDF
4. Obesity: Epidemiology, Pathophysiology, and Therapeutics
   Xihua Lin, Hong Li · 2021 · 1,268 citations · Free PDF
5. Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings
   Nicholas A. Steinmetz, Çağatay Aydın et al. · 2021 · 1,179 citations · Free PDF
6. Leptin and Obesity: Role and Clinical Implication
   Milan M. Obradovic, Emina M. Sudar-Milovanovic et al. · 2021 · 1,111 citations · Free PDF
7. Hearing loss prevalence and years lived with disability, 1990–2019: findings from the Global Burden of Disease Study 2019
   Lydia M Haile, Kaloyan Kamenov et al. · 2021 · 1,110 citations · Free PDF
8. Stanford Neuromodulation Therapy (SNT): A Double-Blind Randomized Controlled Trial
   Eleanor J. Cole, Angela L. Phillips et al. · 2021 · 793 citations
9. The semantics of microglia activation: neuroinflammation, homeostasis, and stress
   Samuel C. Woodburn, Justin L. Bollinger et al. · 2021 · 781 citations · Free PDF
10. The blood–brain barrier in systemic infection and inflammation
    Ian Galea · 2021 · 741 citations · Free PDF
11. Annual Research Review: Shifting from ‘normal science’ to neurodiversity in autism science
    Elizabeth Pellicano, Jacquiline den Houting · 2021 · 727 citations
12. An Attention-Based Deep Learning Approach for Sleep Stage Classification With Single-Channel EEG
    Emadeldeen Eldele, Zhenghua Chen et al. · 2021 · 699 citations
13. Cognitive and behavioural flexibility: neural mechanisms and clinical considerations
    Lucina Q. Uddin · 2021 · 696 citations · Free PDF
14. Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma
    Andrea Cugurra, Tornike Mamuladze et al. · 2021 · 672 citations
15. Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction
    Fuyuko Takata, Shinsuke Nakagawa et al. · 2021 · 641 citations
16. Brain tumor segmentation based on deep learning and an attention mechanism using MRI multi-modalities brain images
    Ramin Ranjbarzadeh, Abbas Bagherian Kasgari et al. · 2021 · 635 citations · Free PDF
17. A brain-computer interface that evokes tactile sensations improves robotic arm control
    Sharlene N. Flesher, John E. Downey et al. · 2021 · 615 citations · Free PDF
18. Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus
    Madoka Nakajima, Shigeki Yamada et al. · 2021 · 598 citations · Free PDF
19. Fluid transport in the brain
    Martin Kaag Rasmussen, Humberto Mestre et al. · 2021 · 598 citations
20. Evidence-Based Practices for Children, Youth, and Young Adults with Autism: Third Generation Review
    Kara Hume, Jessica R. Dykstra Steinbrenner et al. · 2021 · 594 citations · Free PDF
21. A Conceptual Analysis of Autistic Masking: Understanding the Narrative of Stigma and the Illusion of Choice
    Amy Pearson, Kieran Rose · 2021 · 593 citations
22. MRI-Based Brain Tumor Classification Using Ensemble of Deep Features and Machine Learning Classifiers
    Jaeyong Kang, Zahid Ullah et al. · 2021 · 591 citations · Free PDF
23. Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria
    David A. Moses, Sean L. Metzger et al. · 2021 · 585 citations
24. The developmental trajectories of executive function from adolescence to old age
    Heather Jane Ferguson, Victoria E.A. Brunsdon et al. · 2021 · 578 citations · Free PDF
25. Microglia and Central Nervous System–Associated Macrophages—From Origin to Disease Modulation
    Marco Prinz, Takahiro Masuda et al. · 2021 · 574 citations

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