Most-cited Immunology and Microbiology papers of 2021, with free PDFs

The 25 most-cited Immunology and Microbiology research papers published in 2021, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. Inflammation and tumor progression: signaling pathways and targeted intervention
   Huakan Zhao, Lei Wu et al. · 2021 · 2,800 citations · Free PDF
2. Sexually Transmitted Infections Treatment Guidelines, 2021
   Kimberly Workowski, Laura H. Bachmann et al. · 2021 · 2,764 citations · Free PDF
3. Pattern recognition receptors in health and diseases
   Danyang Li, Minghua Wu · 2021 · 1,794 citations · Free PDF
4. Macrophage Polarization States in the Tumor Microenvironment
   Ava J. Boutilier, Sherine F. Elsawa · 2021 · 1,620 citations · Free PDF
5. A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells
   Sijin Cheng, Ziyi Li et al. · 2021 · 1,568 citations
6. Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level
   Yingcheng Wu, Shuaixi Yang et al. · 2021 · 1,137 citations
7. Antimicrobial peptides: mechanism of action, activity and clinical potential
   Qiyu Zhang, Zhibin Yan et al. · 2021 · 1,070 citations · Free PDF
8. Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer
   Kai Li, Houhui Shi et al. · 2021 · 991 citations · Free PDF
9. Targeting tumor-associated macrophages to synergize tumor immunotherapy
   Xiaonan Xiang, Jianguo Wang et al. · 2021 · 965 citations · Free PDF
10. mRNA vaccine for cancer immunotherapy
    Lei Miao, Yu Zhang et al. · 2021 · 932 citations · Free PDF
11. The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2018/2019
    European Food Safety Authority · 2021 · 876 citations
12. Global antibiotic consumption and usage in humans, 2000–18: a spatial modelling study
    Annie J. Browne, Michael Give Chipeta et al. · 2021 · 866 citations
13. Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer
    Maik Luu, Zeno Riester et al. · 2021 · 758 citations · Free PDF
14. NADPH Oxidases (NOX): An Overview from Discovery, Molecular Mechanisms to Physiology and Pathology
    Annelise Vermot, Isabelle Petit-Härtlein et al. · 2021 · 756 citations · Free PDF
15. Dendritic Cells Revisited
    Mar Cabeza-Cabrerizo, Ana Cardoso et al. · 2021 · 754 citations
16. The spectrum of inflammatory responses
    Ruslan M. Medzhitov · 2021 · 709 citations
17. Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease
    Paul M. Ridker, Manas A. Rane · 2021 · 694 citations
18. NK cell-based cancer immunotherapy: from basic biology to clinical development
    Sizhe Liu, Vasiliy Galat et al. · 2021 · 689 citations · Free PDF
19. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation
    Yansen Xiao, Min Cong et al. · 2021 · 656 citations
20. Metabolic reprogramming in macrophage responses
    Yang Liu, Ruyi Xu et al. · 2021 · 646 citations
21. Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy
    Ri‐Yao Yang, Linlin Sun et al. · 2021 · 633 citations · Free PDF
22. Functions of ROS in Macrophages and Antimicrobial Immunity
    Marc Herb, Michael Schramm · 2021 · 633 citations · Free PDF
23. Targeting macrophages in cancer immunotherapy
    Zhaojun Duan, Yunping Luo · 2021 · 627 citations · Free PDF
24. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths
    Paul Bastard, Adrian Gervais et al. · 2021 · 613 citations · Free PDF
25. T cell receptor (TCR) signaling in health and disease
    Kinjal Shah, Amr A. Al-Haidari et al. · 2021 · 606 citations · Free PDF

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