“A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells” (2021), by Sijin Cheng et al. Immunology and Microbiology research paper. Original abstract below, unchanged. No free PDF was found.

A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

Sijin Cheng, Ziyi Li, Ranran Gao et al. · February 1, 2021 · Immunology and Microbiology

Abstract

cDCs revealed their differences in transcription factors and external stimulus. Additionally, pro-angiogenic tumor-associated macrophages (TAMs) were characterized with diverse markers across different cancer types, and the composition of TIMs appeared to be associated with certain features of somatic mutations and gene expressions. Our results provide a systematic view of the highly heterogeneous TIMs and suggest future avenues for rational, targeted immunotherapies.

Source page DOI: 10.1016/j.cell.2021.01.010