# Most-cited Neuroscience papers of 2025, with free PDFs

The 25 most-cited Neuroscience research papers published in 2025, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. [Prevalence and Early Identification of Autism Spectrum Disorder Among Children Aged 4 and 8 Years — Autism and Developmental Disabilities Monitoring Network, 16 Sites, United States, 2022](https://nerdi.pages.dev/paper/W4409458169) · 810 citations · Free PDF
2. [Neuroinflammation across neurological diseases](https://nerdi.pages.dev/paper/W4411505752) · 271 citations
3. [The Role of GABA in the Pathophysiology and Treatment of Anxiety Disorders](https://nerdi.pages.dev/paper/W2254153761) · 263 citations
4. [Mechanisms of GLP-1 Receptor Agonist-Induced Weight Loss: A Review of Central and Peripheral Pathways in Appetite and Energy Regulation](https://nerdi.pages.dev/paper/W4406979066) · 228 citations
5. [Long somatic DNA-repeat expansion drives neurodegeneration in Huntington’s disease](https://nerdi.pages.dev/paper/W4406464838) · 206 citations
6. [A Meta-analysis of Repetitive Transcranial Magnetic Stimulation in the Treatment of Depression](https://nerdi.pages.dev/paper/W27263993) · 201 citations
7. [Chronic Stress-Associated Depressive Disorders: The Impact of HPA Axis Dysregulation and Neuroinflammation on the Hippocampus—A Mini Review](https://nerdi.pages.dev/paper/W4408777577) · 199 citations
8. [The lab streaming layer for synchronized multimodal recording](https://nerdi.pages.dev/paper/W4413273653) · 199 citations · Free PDF
9. [A review of deep learning for brain tumor analysis in MRI](https://nerdi.pages.dev/paper/W4406039681) · 193 citations · Free PDF
10. [Functional connectomics spanning multiple areas of mouse visual cortex](https://nerdi.pages.dev/paper/W4409283533) · 193 citations
11. [Treatment of Autism Spectrum Disorder in Children and Adolescents](https://nerdi.pages.dev/paper/W2540591581) · 178 citations
12. [A brain-wide map of neural activity during complex behaviour](https://nerdi.pages.dev/paper/W4413946593) · 177 citations · Free PDF
13. [Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression](https://nerdi.pages.dev/paper/W4407187138) · 146 citations · Free PDF
14. [From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine](https://nerdi.pages.dev/paper/W4409964596) · 146 citations · Free PDF
15. [Neuroinflammation—A Crucial Factor in the Pathophysiology of Depression—A Comprehensive Review](https://nerdi.pages.dev/paper/W4409002621) · 144 citations
16. [Neural Manifold Decoder for Acupuncture Stimulations With Representation Learning: An Acupuncture-Brain Interface](https://nerdi.pages.dev/paper/W4406521461) · 142 citations
17. [Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease](https://nerdi.pages.dev/paper/W4407956550) · 141 citations
18. [The Glutamate/ GABA ‐Glutamine Cycle: Insights, Updates, and Advances](https://nerdi.pages.dev/paper/W4408308132) · 140 citations
19. [Bio-inspired electronics: Soft, biohybrid, and “living” neural interfaces](https://nerdi.pages.dev/paper/W4407802966) · 137 citations · Free PDF
20. [Interaction of the Vagus Nerve and Serotonin in the Gut–Brain Axis](https://nerdi.pages.dev/paper/W4406932261) · 131 citations · Free PDF
21. [Microglial activation states and their implications for Alzheimer's Disease](https://nerdi.pages.dev/paper/W4406235440) · 130 citations
22. [Tryptophan Depletion, Serotonin, and Depression: Where Do We Stand?](https://nerdi.pages.dev/paper/W49677012) · 130 citations
23. [Advanced Brain Tumor Classification in MR Images Using Transfer Learning and Pre-Trained Deep CNN Models](https://nerdi.pages.dev/paper/W4405995154) · 121 citations · Free PDF
24. [Breaking the Barrier: The Role of Proinflammatory Cytokines in BBB Dysfunction](https://nerdi.pages.dev/paper/W4409284219) · 118 citations · Free PDF
25. [Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an update](https://nerdi.pages.dev/paper/W4410481920) · 118 citations · Free PDF

Canonical page: https://nerdi.pages.dev/papers/neuroscience/most-cited-2025