# Most-cited Neuroscience papers of 2023, with free PDFs

The 25 most-cited Neuroscience research papers published in 2023, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. [Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2020](https://nerdi.pages.dev/paper/W4360600181) · 2,671 citations · Free PDF
2. [The blood–brain barrier: Structure, regulation and drug delivery](https://nerdi.pages.dev/paper/W4378217890) · 1,854 citations · Free PDF
3. [Role of neuroinflammation in neurodegeneration development](https://nerdi.pages.dev/paper/W4383894096) · 1,630 citations · Free PDF
4. [Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets](https://nerdi.pages.dev/paper/W4386913845) · 1,574 citations · Free PDF
5. [Prevalence of autism spectrum disorder among children aged 8 Years - Autism and developmental disabilities monitoring network, 11 Sites, United States, 2014](https://nerdi.pages.dev/paper/W3026621361) · 1,381 citations
6. [cGAS–STING drives ageing-related inflammation and neurodegeneration](https://nerdi.pages.dev/paper/W4385498418) · 1,031 citations · Free PDF
7. [Tryptophan metabolism in health and disease](https://nerdi.pages.dev/paper/W4381620517) · 960 citations
8. [Autism Spectrum Disorder](https://nerdi.pages.dev/paper/W4315436281) · 942 citations
9. [MRI-based brain tumor detection using convolutional deep learning methods and chosen machine learning techniques](https://nerdi.pages.dev/paper/W4317802907) · 618 citations · Free PDF
10. [A somato-cognitive action network alternates with effector regions in motor cortex](https://nerdi.pages.dev/paper/W4366452046) · 597 citations · Free PDF
11. [A high-performance speech neuroprosthesis](https://nerdi.pages.dev/paper/W4386091044) · 575 citations · Free PDF
12. [Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories](https://nerdi.pages.dev/paper/W4376279472) · 560 citations · Free PDF
13. [The Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders](https://nerdi.pages.dev/paper/W4389143877) · 550 citations · Free PDF
14. [TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases](https://nerdi.pages.dev/paper/W4383101597) · 519 citations · Free PDF
15. [Brain Tumor Detection Based on Deep Learning Approaches and Magnetic Resonance Imaging](https://nerdi.pages.dev/paper/W4385987583) · 495 citations · Free PDF
16. [Human microglial state dynamics in Alzheimer’s disease progression](https://nerdi.pages.dev/paper/W4387142551) · 450 citations
17. [The connectome of an insect brain](https://nerdi.pages.dev/paper/W4323809195) · 446 citations · Free PDF
18. [Geometric constraints on human brain function](https://nerdi.pages.dev/paper/W4378901443) · 446 citations · Free PDF
19. [Astrocytes in human central nervous system diseases: a frontier for new therapies](https://nerdi.pages.dev/paper/W4387566775) · 427 citations · Free PDF
20. [Roles of neuropathology-associated reactive astrocytes: a systematic review](https://nerdi.pages.dev/paper/W4324129387) · 421 citations · Free PDF
21. [Inflammatory Processes in Alzheimer’s Disease—Pathomechanism, Diagnosis and Treatment: A Review](https://nerdi.pages.dev/paper/W4362508588) · 409 citations · Free PDF
22. [Immune regulation through tryptophan metabolism](https://nerdi.pages.dev/paper/W4382893287) · 391 citations · Free PDF
23. [Mechanisms of Blood–Brain Barrier Protection by Microbiota-Derived Short-Chain Fatty Acids](https://nerdi.pages.dev/paper/W4321373004) · 386 citations · Free PDF
24. [Transforming the understanding of brain immunity](https://nerdi.pages.dev/paper/W4362661856) · 381 citations
25. [Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression](https://nerdi.pages.dev/paper/W4313888068) · 380 citations · Free PDF

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