# Most-cited Neuroscience papers of 2022, with free PDFs

The 25 most-cited Neuroscience research papers published in 2022, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. [Global prevalence of autism: A systematic review update](https://nerdi.pages.dev/paper/W4214849391) · 3,069 citations
2. [Reproducible brain-wide association studies require thousands of individuals](https://nerdi.pages.dev/paper/W4220838968) · 1,978 citations · Free PDF
3. [EEG Conformer: Convolutional Transformer for EEG Decoding and Visualization](https://nerdi.pages.dev/paper/W4312597583) · 1,093 citations
4. [Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities](https://nerdi.pages.dev/paper/W4224942887) · 954 citations
5. [The Serotonin Theory of Depression: A Systematic Umbrella Review of the Evidence](https://nerdi.pages.dev/paper/W4285891880) · 924 citations · Free PDF
6. [Microglia Polarization From M1 to M2 in Neurodegenerative Diseases](https://nerdi.pages.dev/paper/W4213284669) · 913 citations
7. [Mapping neurotransmitter systems to the structural and functional organization of the human neocortex](https://nerdi.pages.dev/paper/W4307494802) · 790 citations
8. [The blood-brain barrier in aging and neurodegeneration](https://nerdi.pages.dev/paper/W4220819957) · 725 citations · Free PDF
9. [Recommendations for daytime, evening, and nighttime indoor light exposure to best support physiology, sleep, and wakefulness in healthy adults](https://nerdi.pages.dev/paper/W4220935272) · 643 citations · Free PDF
10. [Tight junction proteins occludin and ZO‐1 as regulators of epithelial proliferation and survival](https://nerdi.pages.dev/paper/W4280529994) · 619 citations
11. [Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System](https://nerdi.pages.dev/paper/W4281553262) · 597 citations · Free PDF
12. [Hippocampus and its involvement in Alzheimer’s disease: a review](https://nerdi.pages.dev/paper/W4210493947) · 573 citations · Free PDF
13. [Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression](https://nerdi.pages.dev/paper/W4281689406) · 573 citations · Free PDF
14. [Transcranial magnetic stimulation of the brain: What is stimulated? – A consensus and critical position paper](https://nerdi.pages.dev/paper/W4280629063) · 559 citations
15. [The global prevalence of autism spectrum disorder: a comprehensive systematic review and meta-analysis](https://nerdi.pages.dev/paper/W4284962360) · 558 citations · Free PDF
16. [Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer’s disease](https://nerdi.pages.dev/paper/W4292320039) · 555 citations · Free PDF
17. [Molecular basis of astrocyte diversity and morphology across the CNS in health and disease](https://nerdi.pages.dev/paper/W4308451957) · 548 citations
18. [Global Prevalence and Incidence of Tinnitus](https://nerdi.pages.dev/paper/W4290659914) · 547 citations
19. [Physics-Informed Attention Temporal Convolutional Network for EEG-Based Motor Imagery Classification](https://nerdi.pages.dev/paper/W4300942166) · 521 citations
20. [Microglia regulate central nervous system myelin growth and integrity](https://nerdi.pages.dev/paper/W4311436859) · 499 citations · Free PDF
21. [Maturation and circuit integration of transplanted human cortical organoids](https://nerdi.pages.dev/paper/W4304698283) · 495 citations
22. [Molecular regulations of circadian rhythm and implications for physiology and diseases](https://nerdi.pages.dev/paper/W4210894727) · 466 citations · Free PDF
23. [neuromaps: structural and functional interpretation of brain maps](https://nerdi.pages.dev/paper/W4302362454) · 466 citations · Free PDF
24. [Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases](https://nerdi.pages.dev/paper/W4281395882) · 461 citations · Free PDF
25. [Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes](https://nerdi.pages.dev/paper/W4293068416) · 461 citations

Canonical page: https://nerdi.pages.dev/papers/neuroscience/most-cited-2022