# Most-cited Medicine papers of 2024, with free PDFs

The 25 most-cited Medicine research papers published in 2024, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. [Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries](https://nerdi.pages.dev/paper/W4393935425) · 26,323 citations
2. [Cancer statistics, 2024](https://nerdi.pages.dev/paper/W4390946922) · 9,433 citations
3. [KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease](https://nerdi.pages.dev/paper/W4392777592) · 8,342 citations
4. [2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)](https://nerdi.pages.dev/paper/W4402049769) · 3,016 citations · Free PDF
5. [Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021](https://nerdi.pages.dev/paper/W4396946025) · 2,824 citations · Free PDF
6. [2024 ESC Guidelines for the management of chronic coronary syndromes](https://nerdi.pages.dev/paper/W4402064302) · 2,778 citations
7. [Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup](https://nerdi.pages.dev/paper/W4400089962) · 2,728 citations
8. [2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association](https://nerdi.pages.dev/paper/W4391169031) · 2,654 citations
9. [2024 Alzheimer's disease facts and figures](https://nerdi.pages.dev/paper/W4396560090) · 2,481 citations
10. [Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults](https://nerdi.pages.dev/paper/W4392304105) · 2,448 citations · Free PDF
11. [Cancer incidence and mortality in China, 2022](https://nerdi.pages.dev/paper/W4391671392) · 2,242 citations
12. [EASL–EASD–EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)](https://nerdi.pages.dev/paper/W4399435116) · 2,114 citations
13. [A Phase 3, Randomized, Controlled Trial of Resmetirom in NASH with Liver Fibrosis](https://nerdi.pages.dev/paper/W4391592880) · 2,007 citations
14. [Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes](https://nerdi.pages.dev/paper/W4398781461) · 1,873 citations
15. [A Study to Evaluate Psychological Distress and Self-Esteem Among Patients with Hemodialysis](https://nerdi.pages.dev/paper/W4394726321) · 1,745 citations · Free PDF
16. [World Medical Association Declaration of Helsinki](https://nerdi.pages.dev/paper/W4403560518) · 1,562 citations
17. [World Stroke Organization: Global Stroke Fact Sheet 2025](https://nerdi.pages.dev/paper/W4405078499) · 1,403 citations · Free PDF
18. [Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants](https://nerdi.pages.dev/paper/W4392817459) · 1,397 citations · Free PDF
19. [2. Diagnosis and Classification of Diabetes: Standards of Care in Diabetes—2025](https://nerdi.pages.dev/paper/W4405187673) · 1,340 citations
20. [CAT: a computational anatomy toolbox for the analysis of structural MRI data](https://nerdi.pages.dev/paper/W4401338748) · 1,293 citations · Free PDF
21. [Editor's Choice -- European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Abdominal Aorto-Iliac Artery Aneurysms](https://nerdi.pages.dev/paper/W4391147054) · 1,205 citations · Free PDF
22. [Exploring treatment options in cancer: tumor treatment strategies](https://nerdi.pages.dev/paper/W4400748356) · 1,166 citations
23. [Recent advances in Alzheimer’s disease: mechanisms, clinical trials and new drug development strategies](https://nerdi.pages.dev/paper/W4401806028) · 1,142 citations · Free PDF
24. [Enfortumab Vedotin and Pembrolizumab in Untreated Advanced Urothelial Cancer](https://nerdi.pages.dev/paper/W4392498919) · 1,097 citations
25. [Percutaneous polymethylmethacrylate vertebroplasty in the treatment of osteoporotic vertebral body compression fractures: technical aspects](https://nerdi.pages.dev/paper/W2109413851) · 1,091 citations

Canonical page: https://nerdi.pages.dev/papers/medicine/most-cited-2024