# Most-cited Medicine papers of 2022, with free PDFs

The 25 most-cited Medicine research papers published in 2022, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. [Cancer statistics, 2022](https://nerdi.pages.dev/paper/W4206841660) · 17,229 citations
2. [Hallmarks of Cancer: New Dimensions](https://nerdi.pages.dev/paper/W4206662285) · 9,565 citations
3. [Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association](https://nerdi.pages.dev/paper/W4210242902) · 5,977 citations
4. [Lecanemab in Early Alzheimer’s Disease](https://nerdi.pages.dev/paper/W4310461604) · 5,580 citations
5. [Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019](https://nerdi.pages.dev/paper/W4206055706) · 5,502 citations · Free PDF
6. [The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms](https://nerdi.pages.dev/paper/W4283271244) · 4,215 citations · Free PDF
7. [The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms](https://nerdi.pages.dev/paper/W4283381496) · 4,008 citations · Free PDF
8. [Tirzepatide Once Weekly for the Treatment of Obesity](https://nerdi.pages.dev/paper/W4281934192) · 3,716 citations
9. [Cancer treatment and survivorship statistics, 2022](https://nerdi.pages.dev/paper/W4283313052) · 3,628 citations
10. [Cancer statistics in China and United States, 2022: profiles, trends, and determinants](https://nerdi.pages.dev/paper/W4211038303) · 3,419 citations
11. [Current and future burden of breast cancer: Global statistics for 2020 and 2040](https://nerdi.pages.dev/paper/W4294189863) · 3,375 citations
12. [Global burden of heart failure: a comprehensive and updated review of epidemiology](https://nerdi.pages.dev/paper/W4210937888) · 3,317 citations
13. [Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN](https://nerdi.pages.dev/paper/W4284884567) · 3,275 citations
14. [Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications](https://nerdi.pages.dev/paper/W4284889683) · 3,068 citations
15. [World Stroke Organization (WSO): Global Stroke Fact Sheet 2022](https://nerdi.pages.dev/paper/W4205679663) · 2,983 citations
16. [Mapping genomic loci implicates genes and synaptic biology in schizophrenia](https://nerdi.pages.dev/paper/W4223520055) · 2,960 citations · Free PDF
17. [International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data](https://nerdi.pages.dev/paper/W4283716970) · 2,893 citations
18. [Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction](https://nerdi.pages.dev/paper/W4293354639) · 2,849 citations · Free PDF
19. [Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline](https://nerdi.pages.dev/paper/W4225147016) · 2,829 citations
20. [Life’s Essential 8: Updating and Enhancing the American Heart Association’s Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association](https://nerdi.pages.dev/paper/W4283695295) · 2,734 citations · Free PDF
21. [Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer](https://nerdi.pages.dev/paper/W4281640394) · 2,667 citations
22. [Empagliflozin in Patients with Chronic Kidney Disease](https://nerdi.pages.dev/paper/W4308183941) · 2,665 citations
23. [New insights into the genetic etiology of Alzheimer’s disease and related dementias](https://nerdi.pages.dev/paper/W4223591189) · 2,500 citations · Free PDF
24. [2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes—2023](https://nerdi.pages.dev/paper/W4311263986) · 2,438 citations
25. [Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN](https://nerdi.pages.dev/paper/W4295096627) · 2,385 citations

Canonical page: https://nerdi.pages.dev/papers/medicine/most-cited-2022