# Most-cited Medicine papers of 2019, with free PDFs

The 25 most-cited Medicine research papers published in 2019, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. [Cancer statistics, 2019](https://nerdi.pages.dev/paper/W2911188335) · 20,202 citations
2. [2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk](https://nerdi.pages.dev/paper/W3183857127) · 9,006 citations
3. [Integrated genomic analyses of ovarian carcinoma](https://nerdi.pages.dev/paper/W4298324324) · 7,951 citations
4. [Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association](https://nerdi.pages.dev/paper/W2982303713) · 7,489 citations
5. [2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes](https://nerdi.pages.dev/paper/W3011371150) · 7,181 citations
6. [Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction](https://nerdi.pages.dev/paper/W2974260792) · 7,100 citations
7. [2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines](https://nerdi.pages.dev/paper/W2900034165) · 6,192 citations
8. [Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy](https://nerdi.pages.dev/paper/W2939222610) · 6,148 citations
9. [Health effects of dietary risks in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017](https://nerdi.pages.dev/paper/W2928467655) · 5,791 citations · Free PDF
10. [2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS)](https://nerdi.pages.dev/paper/W2971121646) · 4,932 citations · Free PDF
11. [Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients](https://nerdi.pages.dev/paper/W2921388585) · 4,857 citations
12. [2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk](https://nerdi.pages.dev/paper/W2953804067) · 4,856 citations · Free PDF
13. [2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD](https://nerdi.pages.dev/paper/W2150959326) · 4,784 citations
14. [2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines](https://nerdi.pages.dev/paper/W2921012991) · 4,505 citations
15. [Hepatocellular Carcinoma](https://nerdi.pages.dev/paper/W4232620598) · 4,476 citations
16. [Machine Learning in Medicine](https://nerdi.pages.dev/paper/W2934399013) · 4,428 citations
17. [Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis](https://nerdi.pages.dev/paper/W2959442417) · 4,286 citations · Free PDF
18. [Cancer treatment and survivorship statistics, 2019](https://nerdi.pages.dev/paper/W2951071083) · 4,244 citations
19. [Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement](https://nerdi.pages.dev/paper/W2981067716) · 4,241 citations
20. [Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis](https://nerdi.pages.dev/paper/W2993250673) · 4,124 citations
21. [Global trends in insufficient physical activity among adolescents: a pooled analysis of 298 population-based surveys with 1·6 million participants](https://nerdi.pages.dev/paper/W2989617484) · 3,995 citations
22. [Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range](https://nerdi.pages.dev/paper/W2948261890) · 3,971 citations
23. [The potential for artificial intelligence in healthcare](https://nerdi.pages.dev/paper/W2953532875) · 3,778 citations · Free PDF
24. [Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma](https://nerdi.pages.dev/paper/W3043703771) · 3,712 citations · Free PDF
25. [Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients](https://nerdi.pages.dev/paper/W2922215374) · 3,681 citations

Canonical page: https://nerdi.pages.dev/papers/medicine/most-cited-2019