# Most-cited Medicine papers of 2018, with free PDFs

The 25 most-cited Medicine research papers published in 2018, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. [Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries](https://nerdi.pages.dev/paper/W2889646458) · 84,371 citations
2. [Cancer statistics, 2018](https://nerdi.pages.dev/paper/W2781525129) · 16,596 citations
3. [Sarcopenia: revised European consensus on definition and diagnosis](https://nerdi.pages.dev/paper/W2897513125) · 13,852 citations
4. [International Diabetes Federation 2017](https://nerdi.pages.dev/paper/W2789732774) · 13,442 citations
5. [Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition](https://nerdi.pages.dev/paper/W2801085490) · 10,749 citations
6. [NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease](https://nerdi.pages.dev/paper/W2798054687) · 10,498 citations
7. [2018 ESC/ESH Guidelines for the management of arterial hypertension](https://nerdi.pages.dev/paper/W2888589263) · 10,326 citations · Free PDF
8. [The Physical Activity Guidelines for Americans](https://nerdi.pages.dev/paper/W2900726805) · 9,634 citations
9. [Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods](https://nerdi.pages.dev/paper/W2895926103) · 7,583 citations
10. [2018 ESC/EACTS Guidelines on myocardial revascularization](https://nerdi.pages.dev/paper/W2916912835) · 7,165 citations
11. [Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association](https://nerdi.pages.dev/paper/W2791453970) · 7,132 citations
12. [Cancer immunotherapy using checkpoint blockade](https://nerdi.pages.dev/paper/W2791483720) · 6,731 citations
13. [Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer](https://nerdi.pages.dev/paper/W2796582438) · 6,605 citations
14. [Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes](https://nerdi.pages.dev/paper/W2900413769) · 6,368 citations
15. [Fourth universal definition of myocardial infarction (2018)](https://nerdi.pages.dev/paper/W2888543854) · 5,888 citations
16. [The Immune Landscape of Cancer](https://nerdi.pages.dev/paper/W2796207838) · 5,774 citations · Free PDF
17. [Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia](https://nerdi.pages.dev/paper/W2787301955) · 5,694 citations
18. [Origin and evolution of pathogenic coronaviruses](https://nerdi.pages.dev/paper/W2903899730) · 5,564 citations · Free PDF
19. [Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017](https://nerdi.pages.dev/paper/W2899773405) · 4,948 citations · Free PDF
20. [Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging](https://nerdi.pages.dev/paper/W2787867590) · 4,940 citations
21. [Immune-Related Adverse Events Associated with Immune Checkpoint Blockade](https://nerdi.pages.dev/paper/W2783137027) · 4,822 citations
22. [Convolutional neural networks: an overview and application in radiology](https://nerdi.pages.dev/paper/W2809254203) · 4,682 citations · Free PDF
23. [Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma](https://nerdi.pages.dev/paper/W2792937256) · 4,649 citations · Free PDF
24. [Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases](https://nerdi.pages.dev/paper/W2796067155) · 4,552 citations
25. [Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance](https://nerdi.pages.dev/paper/W2791839818) · 4,296 citations

Canonical page: https://nerdi.pages.dev/papers/medicine/most-cited-2018