# Most-cited Medicine papers of 2017, with free PDFs

The 25 most-cited Medicine research papers published in 2017, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. [Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review](https://nerdi.pages.dev/paper/W2572174216) · 15,262 citations
2. [Cancer statistics, 2017](https://nerdi.pages.dev/paper/W2570618306) · 14,732 citations
3. [Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice](https://nerdi.pages.dev/paper/W2620241325) · 10,686 citations
4. [2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation](https://nerdi.pages.dev/paper/W2754054868) · 9,744 citations
5. [The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function](https://nerdi.pages.dev/paper/W2620406790) · 8,483 citations
6. [Health Effects of Overweight and Obesity in 195 Countries over 25 Years](https://nerdi.pages.dev/paper/W2735376054) · 7,904 citations
7. [Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes](https://nerdi.pages.dev/paper/W2626446274) · 7,822 citations · Free PDF
8. [Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults](https://nerdi.pages.dev/paper/W2762689525) · 7,503 citations · Free PDF
9. [2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines](https://nerdi.pages.dev/paper/W2770837559) · 7,384 citations
10. [The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases](https://nerdi.pages.dev/paper/W2734724639) · 7,234 citations
11. [An Overview of Heart Rate Variability Metrics and Norms](https://nerdi.pages.dev/paper/W2759190050) · 7,145 citations · Free PDF
12. [Intravenous Fluids and Acute Kidney Injury](https://nerdi.pages.dev/paper/W2581605534) · 6,831 citations
13. [Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade](https://nerdi.pages.dev/paper/W2622499649) · 6,616 citations
14. [Computational Radiomics System to Decode the Radiographic Phenotype](https://nerdi.pages.dev/paper/W2767128594) · 6,551 citations
15. [The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population‐based to a more “personalized” approach to cancer staging](https://nerdi.pages.dev/paper/W2573152477) · 6,521 citations
16. [2017 ESC/EACTS Guidelines for the management of valvular heart disease](https://nerdi.pages.dev/paper/W2751630023) · 6,256 citations · Free PDF
17. [Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease](https://nerdi.pages.dev/paper/W2596179513) · 6,131 citations
18. [Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma](https://nerdi.pages.dev/paper/W2773804840) · 6,000 citations
19. [TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells](https://nerdi.pages.dev/paper/W2765224588) · 5,950 citations
20. [Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct](https://nerdi.pages.dev/paper/W2767776410) · 5,638 citations
21. [Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors](https://nerdi.pages.dev/paper/W2765314233) · 5,622 citations
22. [Osimertinib in Untreated EGFR -Mutated Advanced Non–Small-Cell Lung Cancer](https://nerdi.pages.dev/paper/W2770828094) · 5,384 citations
23. [Acute Abdomen: A Rare Case of Ruptured Hepatocellular Carcinoma](https://nerdi.pages.dev/paper/W2597872842) · 5,371 citations
24. [Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma](https://nerdi.pages.dev/paper/W2753432434) · 5,348 citations
25. [Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury](https://nerdi.pages.dev/paper/W2743254891) · 5,203 citations

Canonical page: https://nerdi.pages.dev/papers/medicine/most-cited-2017