# Most-cited Immunology and Microbiology papers of 2022, with free PDFs

The 25 most-cited Immunology and Microbiology research papers published in 2022, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. [Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis](https://nerdi.pages.dev/paper/W4206677002) · 16,136 citations · Free PDF
2. [Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019](https://nerdi.pages.dev/paper/W4309503005) · 2,231 citations · Free PDF
3. [Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022](https://nerdi.pages.dev/paper/W4286383196) · 2,153 citations · Free PDF
4. [The changing epidemiology of human monkeypox—A potential threat? A systematic review](https://nerdi.pages.dev/paper/W4211060053) · 1,946 citations
5. [Clinical features and management of human monkeypox: a retrospective observational study in the UK](https://nerdi.pages.dev/paper/W4281477179) · 1,261 citations
6. [Atherosclerosis: Recent developments](https://nerdi.pages.dev/paper/W4225287557) · 1,251 citations
7. [Inflammation and atherosclerosis: signaling pathways and therapeutic intervention](https://nerdi.pages.dev/paper/W4224251997) · 1,167 citations · Free PDF
8. [Human Inborn Errors of Immunity: 2022 Update on the Classification from the International Union of Immunological Societies Expert Committee](https://nerdi.pages.dev/paper/W4283363193) · 1,160 citations · Free PDF
9. [Pathophysiology of Atherosclerosis](https://nerdi.pages.dev/paper/W4220799853) · 1,013 citations · Free PDF
10. [Toll-Like Receptor Signaling and Its Role in Cell-Mediated Immunity](https://nerdi.pages.dev/paper/W4214925106) · 969 citations · Free PDF
11. [Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer](https://nerdi.pages.dev/paper/W4221123198) · 952 citations · Free PDF
12. [Germinal Centers](https://nerdi.pages.dev/paper/W4210658740) · 827 citations
13. [Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus](https://nerdi.pages.dev/paper/W4283360071) · 825 citations · Free PDF
14. [The Role of Inflammation in Cardiovascular Disease](https://nerdi.pages.dev/paper/W4307551227) · 725 citations · Free PDF
15. [Cancer vaccines as promising immuno-therapeutics: platforms and current progress](https://nerdi.pages.dev/paper/W4220679821) · 715 citations · Free PDF
16. [Macrophage diversity in cancer revisited in the era of single-cell omics](https://nerdi.pages.dev/paper/W4282943635) · 705 citations
17. [Neutrophils in chronic inflammatory diseases](https://nerdi.pages.dev/paper/W4206756949) · 694 citations · Free PDF
18. [Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study](https://nerdi.pages.dev/paper/W4292083143) · 686 citations
19. [The past, present, and future of antibiotics](https://nerdi.pages.dev/paper/W4291020097) · 653 citations
20. [Advances in the pathogenesis of psoriasis: from keratinocyte perspective](https://nerdi.pages.dev/paper/W4207039412) · 633 citations · Free PDF
21. [Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series](https://nerdi.pages.dev/paper/W4288440919) · 618 citations
22. [Immunosuppressive cells in cancer: mechanisms and potential therapeutic targets](https://nerdi.pages.dev/paper/W4280488282) · 588 citations · Free PDF
23. [Roles of natural killer cells in immunity to cancer, and applications to immunotherapy](https://nerdi.pages.dev/paper/W4281826746) · 576 citations
24. [Antimicrobial resistance: One Health approach](https://nerdi.pages.dev/paper/W4220744632) · 572 citations
25. [Epidemiological, clinical and virological characteristics of four cases of monkeypox support transmission through sexual contact, Italy, May 2022](https://nerdi.pages.dev/paper/W4281666791) · 562 citations · Free PDF

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