# Most-cited Genetics and Biochemistry papers of 2025, with free PDFs

The 25 most-cited Genetics and Biochemistry research papers published in 2025, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. [Breast cancer: pathogenesis and treatments](https://nerdi.pages.dev/paper/W4407681133) · 949 citations · Free PDF
2. [Simulating 500 million years of evolution with a language model](https://nerdi.pages.dev/paper/W4406440058) · 916 citations
3. [edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets](https://nerdi.pages.dev/paper/W4406778273) · 821 citations · Free PDF
4. [Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances](https://nerdi.pages.dev/paper/W4411192949) · 790 citations · Free PDF
5. [CoverM: read alignment statistics for metagenomics](https://nerdi.pages.dev/paper/W4409229284) · 513 citations · Free PDF
6. [NF-κB in inflammation and cancer](https://nerdi.pages.dev/paper/W4411619062) · 486 citations · Free PDF
7. [The intestinal barrier: a pivotal role in health, inflammation, and cancer](https://nerdi.pages.dev/paper/W4408308851) · 484 citations
8. [Lactate and lactylation in cancer](https://nerdi.pages.dev/paper/W4407356924) · 470 citations · Free PDF
9. [Cellpose3: one-click image restoration for improved cellular segmentation](https://nerdi.pages.dev/paper/W4407415768) · 464 citations · Free PDF
10. [Global evolution of inflammatory bowel disease across epidemiologic stages](https://nerdi.pages.dev/paper/W4410019431) · 454 citations · Free PDF
11. [Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines](https://nerdi.pages.dev/paper/W4408129349) · 411 citations
12. [Energy metabolism in health and diseases](https://nerdi.pages.dev/paper/W4407711657) · 396 citations
13. [The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy](https://nerdi.pages.dev/paper/W4408663412) · 387 citations · Free PDF
14. [Patient-Specific In Vivo Gene Editing to Treat a Rare Genetic Disease](https://nerdi.pages.dev/paper/W4410396192) · 367 citations
15. [Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives](https://nerdi.pages.dev/paper/W4410473472) · 357 citations
16. [Oxidative Stress: Signaling Pathways, Biological Functions, and Disease](https://nerdi.pages.dev/paper/W4411907932) · 355 citations
17. [Scalable emulation of protein equilibrium ensembles with generative deep learning](https://nerdi.pages.dev/paper/W4412165572) · 335 citations
18. [The gut microbiota-immune-brain axis: Therapeutic implications](https://nerdi.pages.dev/paper/W4408301706) · 318 citations
19. [Redox regulation: mechanisms, biology and therapeutic targets in diseases](https://nerdi.pages.dev/paper/W4408177304) · 313 citations
20. [Segment Anything for Microscopy](https://nerdi.pages.dev/paper/W4407415703) · 306 citations · Free PDF
21. [Gut Microbiota Dysbiosis: Pathogenesis, Diseases, Prevention, and Therapy](https://nerdi.pages.dev/paper/W4409564053) · 299 citations
22. [High-definition spatial transcriptomic profiling of immune cell populations in colorectal cancer](https://nerdi.pages.dev/paper/W4411069266) · 298 citations
23. [NLRP3 inflammasome in neuroinflammation and central nervous system diseases](https://nerdi.pages.dev/paper/W4408419977) · 295 citations
24. [MIQE 2.0: Revision of the Minimum Information for Publication of Quantitative Real-Time PCR Experiments Guidelines](https://nerdi.pages.dev/paper/W4409736934) · 286 citations
25. [Atomic context-conditioned protein sequence design using LigandMPNN](https://nerdi.pages.dev/paper/W4408934460) · 282 citations · Free PDF

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