# Most-cited Genetics and Biochemistry papers of 2023, with free PDFs

The 25 most-cited Genetics and Biochemistry research papers published in 2023, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. [Evolutionary-scale prediction of atomic-level protein structure with a language model](https://nerdi.pages.dev/paper/W4327550249) · 5,519 citations · Free PDF
2. [UCSF ChimeraX : Tools for structure building and analysis](https://nerdi.pages.dev/paper/W4387164156) · 4,525 citations
3. [FinnGen provides genetic insights from a well-phenotyped isolated population](https://nerdi.pages.dev/paper/W4317390883) · 4,185 citations · Free PDF
4. [The Gene Ontology knowledgebase in 2023](https://nerdi.pages.dev/paper/W4323036511) · 2,687 citations · Free PDF
5. [Fast and accurate protein structure search with Foldseek](https://nerdi.pages.dev/paper/W4375858802) · 2,616 citations · Free PDF
6. [De novo design of protein structure and function with RFdiffusion](https://nerdi.pages.dev/paper/W4383957026) · 2,306 citations · Free PDF
7. [Ultrafast one‐pass FASTQ data preprocessing, quality control, and deduplication using fastp](https://nerdi.pages.dev/paper/W4375863320) · 2,139 citations
8. [Accurate proteome-wide missense variant effect prediction with AlphaMissense](https://nerdi.pages.dev/paper/W4386861232) · 2,129 citations
9. [PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer](https://nerdi.pages.dev/paper/W4385986528) · 2,095 citations · Free PDF
10. [AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences](https://nerdi.pages.dev/paper/W4388464011) · 2,030 citations
11. [Proksee: in-depth characterization and visualization of bacterial genomes](https://nerdi.pages.dev/paper/W4368358104) · 1,898 citations
12. [MitoHiFi: a python pipeline for mitochondrial genome assembly from PacBio high fidelity reads](https://nerdi.pages.dev/paper/W4384652177) · 1,896 citations · Free PDF
13. [Plasma proteomic associations with genetics and health in the UK Biobank](https://nerdi.pages.dev/paper/W4387344289) · 1,804 citations · Free PDF
14. [g:Profiler—interoperable web service for functional enrichment analysis and gene identifier mapping (2023 update)](https://nerdi.pages.dev/paper/W4372332501) · 1,670 citations
15. [Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions](https://nerdi.pages.dev/paper/W4321167021) · 1,570 citations · Free PDF
16. [The Reactome Pathway Knowledgebase 2024](https://nerdi.pages.dev/paper/W4388539829) · 1,490 citations
17. [Extending and improving metagenomic taxonomic profiling with uncharacterized species using MetaPhlAn 4](https://nerdi.pages.dev/paper/W4321611856) · 1,428 citations · Free PDF
18. [Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review](https://nerdi.pages.dev/paper/W4385330162) · 1,371 citations · Free PDF
19. [Tree Visualization By One Table (tvBOT): a web application for visualizing, modifying and annotating phylogenetic trees](https://nerdi.pages.dev/paper/W4372333115) · 1,363 citations
20. [Angiogenic signaling pathways and anti-angiogenic therapy for cancer](https://nerdi.pages.dev/paper/W4376226672) · 1,299 citations · Free PDF
21. [Next-Generation Sequencing Technology: Current Trends and Advancements](https://nerdi.pages.dev/paper/W4384341779) · 1,272 citations · Free PDF
22. [Mitochondrial dynamics in health and disease: mechanisms and potential targets](https://nerdi.pages.dev/paper/W4386448978) · 1,267 citations · Free PDF
23. [Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota](https://nerdi.pages.dev/paper/W4381832905) · 1,244 citations · Free PDF
24. [Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation](https://nerdi.pages.dev/paper/W4319335680) · 1,186 citations
25. [A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain](https://nerdi.pages.dev/paper/W4389670555) · 1,177 citations · Free PDF

Canonical page: https://nerdi.pages.dev/papers/genetics-and-biochemistry/most-cited-2023