# Most-cited Genetics and Biochemistry papers of 2022, with free PDFs

The 25 most-cited Genetics and Biochemistry research papers published in 2022, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. [ColabFold: making protein folding accessible to all](https://nerdi.pages.dev/paper/W4281790889) · 9,505 citations · Free PDF
2. [The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest](https://nerdi.pages.dev/paper/W4308834893) · 9,430 citations
3. [UniProt: the Universal Protein Knowledgebase in 2023](https://nerdi.pages.dev/paper/W4309506674) · 7,042 citations
4. [DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)](https://nerdi.pages.dev/paper/W4220831425) · 6,201 citations
5. [KEGG for taxonomy-based analysis of pathways and genomes](https://nerdi.pages.dev/paper/W4307425304) · 5,778 citations
6. [Copper induces cell death by targeting lipoylated TCA cycle proteins](https://nerdi.pages.dev/paper/W4221115671) · 4,860 citations
7. [Microbiota in health and diseases](https://nerdi.pages.dev/paper/W4224436908) · 3,135 citations · Free PDF
8. [The complete sequence of a human genome](https://nerdi.pages.dev/paper/W4220999759) · 3,134 citations
9. [SignalP 6.0 predicts all five types of signal peptides using protein language models](https://nerdi.pages.dev/paper/W4205192056) · 2,901 citations · Free PDF
10. [YaHS: yet another Hi-C scaffolding tool](https://nerdi.pages.dev/paper/W4311663808) · 2,479 citations · Free PDF
11. [UALCAN: An update to the integrated cancer data analysis platform](https://nerdi.pages.dev/paper/W4206965224) · 2,457 citations
12. [InterPro in 2022](https://nerdi.pages.dev/paper/W4308616064) · 2,450 citations · Free PDF
13. [Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities](https://nerdi.pages.dev/paper/W4205498896) · 2,425 citations · Free PDF
14. [CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database](https://nerdi.pages.dev/paper/W4306871314) · 2,396 citations
15. [Gut microbiome and health: mechanistic insights](https://nerdi.pages.dev/paper/W4210377299) · 2,363 citations · Free PDF
16. [Search and sequence analysis tools services from EMBL-EBI in 2022](https://nerdi.pages.dev/paper/W4223552703) · 2,324 citations
17. [Therapeutic peptides: current applications and future directions](https://nerdi.pages.dev/paper/W4212959738) · 2,100 citations · Free PDF
18. [GTDB-Tk v2: memory friendly classification with the genome taxonomy database](https://nerdi.pages.dev/paper/W4304481015) · 2,081 citations · Free PDF
19. [Robust deep learning–based protein sequence design using ProteinMPNN](https://nerdi.pages.dev/paper/W4296032638) · 2,070 citations · Free PDF
20. [SignalP 6.0 predicts all five types of signal peptides using protein language models](https://nerdi.pages.dev/paper/W4206950245) · 1,939 citations
21. [Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics](https://nerdi.pages.dev/paper/W4221040717) · 1,828 citations
22. [Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays](https://nerdi.pages.dev/paper/W4229033508) · 1,767 citations
23. [Aging and aging-related diseases: from molecular mechanisms to interventions and treatments](https://nerdi.pages.dev/paper/W4311744984) · 1,717 citations · Free PDF
24. [The NHGRI-EBI GWAS Catalog: knowledgebase and deposition resource](https://nerdi.pages.dev/paper/W4308616307) · 1,656 citations
25. [The role of ROS in tumour development and progression](https://nerdi.pages.dev/paper/W4210498051) · 1,597 citations

Canonical page: https://nerdi.pages.dev/papers/genetics-and-biochemistry/most-cited-2022