# Most-cited Genetics and Biochemistry papers of 2018, with free PDFs

The 25 most-cited Genetics and Biochemistry research papers published in 2018, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. [MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms](https://nerdi.pages.dev/paper/W2799524357) · 37,738 citations
2. [fastp: an ultra-fast all-in-one FASTQ preprocessor](https://nerdi.pages.dev/paper/W2951912016) · 29,614 citations · Free PDF
3. [STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets](https://nerdi.pages.dev/paper/W2900569176) · 17,862 citations
4. [Minimap2: pairwise alignment for nucleotide sequences](https://nerdi.pages.dev/paper/W2789843538) · 15,482 citations · Free PDF
5. [SWISS-MODEL: homology modelling of protein structures and complexes](https://nerdi.pages.dev/paper/W2804822363) · 13,184 citations
6. [Posterior Summarization in Bayesian Phylogenetics Using Tracer 1.7](https://nerdi.pages.dev/paper/W2801159594) · 11,159 citations · Free PDF
7. [Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines](https://nerdi.pages.dev/paper/W2900756811) · 11,018 citations · Free PDF
8. [ape 5.0: an environment for modern phylogenetics and evolutionary analyses in R](https://nerdi.pages.dev/paper/W2883251903) · 9,242 citations
9. [The UK Biobank resource with deep phenotyping and genomic data](https://nerdi.pages.dev/paper/W2895486342) · 8,970 citations · Free PDF
10. [SCANPY: large-scale single-cell gene expression data analysis](https://nerdi.pages.dev/paper/W2800392236) · 8,879 citations · Free PDF
11. [The MR-Base platform supports systematic causal inference across the human phenome](https://nerdi.pages.dev/paper/W2805983714) · 7,993 citations
12. [UniProt: a worldwide hub of protein knowledge](https://nerdi.pages.dev/paper/W3136918052) · 7,771 citations
13. [Optimizing taxonomic classification of marker-gene amplicon sequences with QIIME 2’s q2-feature-classifier plugin](https://nerdi.pages.dev/paper/W2807194798) · 5,930 citations · Free PDF
14. [High throughput ANI analysis of 90K prokaryotic genomes reveals clear species boundaries](https://nerdi.pages.dev/paper/W2951254987) · 5,736 citations · Free PDF
15. [Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation](https://nerdi.pages.dev/paper/W2811212358) · 5,277 citations · Free PDF
16. [eggNOG 5.0: a hierarchical, functionally and phylogenetically annotated orthology resource based on 5090 organisms and 2502 viruses](https://nerdi.pages.dev/paper/W2900629010) · 4,993 citations
17. [COSMIC: the Catalogue Of Somatic Mutations In Cancer](https://nerdi.pages.dev/paper/W2898789672) · 4,876 citations
18. [The Gene Ontology Resource: 20 years and still GOing strong](https://nerdi.pages.dev/paper/W2950595506) · 4,792 citations
19. [miRBase: from microRNA sequences to function](https://nerdi.pages.dev/paper/W2898440040) · 4,774 citations
20. [New tools for automated high-resolution cryo-EM structure determination in RELION-3](https://nerdi.pages.dev/paper/W2899714098) · 4,713 citations · Free PDF
21. [The Pfam protein families database in 2019](https://nerdi.pages.dev/paper/W2898402099) · 4,634 citations
22. [CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity](https://nerdi.pages.dev/paper/W2787024379) · 4,490 citations · Free PDF
23. [Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians](https://nerdi.pages.dev/paper/W2818417770) · 4,416 citations
24. [Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer](https://nerdi.pages.dev/paper/W2897422388) · 4,359 citations
25. [The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019](https://nerdi.pages.dev/paper/W2901303766) · 4,069 citations

Canonical page: https://nerdi.pages.dev/papers/genetics-and-biochemistry/most-cited-2018