# Most-cited Chemistry papers of 2025, with free PDFs

The 25 most-cited Chemistry research papers published in 2025, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. [Antimicrobial Potential of Polyphenols: Mechanisms of Action and Microbial Responses—A Narrative Review](https://nerdi.pages.dev/paper/W4407320695) · 257 citations · Free PDF
2. [Red analytical performance index (RAPI) and software: the missing tool for assessing methods in terms of analytical performance](https://nerdi.pages.dev/paper/W4409810674) · 199 citations
3. [Click Analytical Chemistry Index as a novel concept and framework, supported with open source software to assess analytical methods](https://nerdi.pages.dev/paper/W4407868107) · 195 citations
4. [Adsorption and Separation by Flexible MOFs](https://nerdi.pages.dev/paper/W4406918026) · 194 citations
5. [A review on spectral data preprocessing techniques for machine learning and quantitative analysis](https://nerdi.pages.dev/paper/W4410856291) · 188 citations
6. [Investigation of Metal-Organic Frameworks (MOFs): Synthesis, Properties, and Applications - An In-Depth Review](https://nerdi.pages.dev/paper/W4408490572) · 180 citations
7. [Highly sensitive laser spectroscopy sensing based on a novel four-prong quartz tuning fork](https://nerdi.pages.dev/paper/W4406707941) · 168 citations
8. [State‐of‐the‐Art, Insights, and Perspectives for MOFs‐Nanocomposites and MOF‐Derived (Nano)Materials](https://nerdi.pages.dev/paper/W4409650168) · 163 citations
9. [Metal–organic framework-based smart stimuli-responsive drug delivery systems for cancer therapy: advances, challenges, and future perspectives](https://nerdi.pages.dev/paper/W4408029392) · 162 citations
10. [Environmental applications of metal–organic framework-based three-dimensional macrostructures: a review](https://nerdi.pages.dev/paper/W4406246614) · 160 citations
11. [Hyperspectral Imaging and Deep Learning for Quality and Safety Inspection of Fruits and Vegetables: A Review](https://nerdi.pages.dev/paper/W4409484815) · 151 citations
12. [Pore engineering in metal–organic frameworks and covalent organic frameworks: strategies and applications](https://nerdi.pages.dev/paper/W4411297920) · 141 citations
13. [ZIF-8 metal–organic frameworks and their hybrid materials: emerging photocatalysts for energy and environmental applications](https://nerdi.pages.dev/paper/W4406428749) · 135 citations
14. [The Cation−π Interaction in Chemistry and Biology](https://nerdi.pages.dev/paper/W4407782185) · 134 citations
15. [Green Analytical Chemistry—Recent Innovations](https://nerdi.pages.dev/paper/W4408337934) · 133 citations
16. [Calibration-free measurement of absolute gas concentration and temperature via light-induced thermoelastic spectroscopy](https://nerdi.pages.dev/paper/W4415096176) · 131 citations
17. [Enhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics](https://nerdi.pages.dev/paper/W4406473173) · 129 citations · Free PDF
18. [Visible light–triggered depolymerization of commercial polymethacrylates](https://nerdi.pages.dev/paper/W4407764659) · 128 citations
19. [Parts-per-quadrillion level gas molecule detection: CO-LITES sensing](https://nerdi.pages.dev/paper/W4410019397) · 124 citations · Free PDF
20. [Recent advances in MOF composites for photocatalysis](https://nerdi.pages.dev/paper/W4411740378) · 124 citations
21. [Molecular Photoelectrocatalysis for Radical Reactions](https://nerdi.pages.dev/paper/W4406333109) · 119 citations
22. [Porosity Tunable Metal-Organic Framework (MOF)-Based Composites for Energy Storage Applications: Recent Progress](https://nerdi.pages.dev/paper/W4406181514) · 116 citations · Free PDF
23. [Intermolecular 1,2-difunctionalization of alkenes](https://nerdi.pages.dev/paper/W4414409886) · 116 citations
24. [Remodelling molecular frameworks via atom-level surgery: recent advances in skeletal editing of (hetero)cycles](https://nerdi.pages.dev/paper/W4406183114) · 114 citations
25. [Advances in Organic Small Molecule-Based Fluorescent Probes for Precision Detection of Liver Diseases: A Perspective on Emerging Trends and Challenges](https://nerdi.pages.dev/paper/W4408147868) · 113 citations

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