Most-cited Chemistry papers of 2025, with free PDFs

The 25 most-cited Chemistry research papers published in 2025, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. Antimicrobial Potential of Polyphenols: Mechanisms of Action and Microbial Responses—A Narrative Review
   Luca De Rossi, Gabriele Rocchetti et al. · 2025 · 257 citations · Free PDF
2. Red analytical performance index (RAPI) and software: the missing tool for assessing methods in terms of analytical performance
   Paweł Mateusz Nowak, W. Wojnowski et al. · 2025 · 199 citations
3. Click Analytical Chemistry Index as a novel concept and framework, supported with open source software to assess analytical methods
   Fotouh R. Mansour, Alaa Bedair et al. · 2025 · 195 citations
4. Adsorption and Separation by Flexible MOFs
   Irena Senkovska, Volodymyr Bon et al. · 2025 · 194 citations
5. A review on spectral data preprocessing techniques for machine learning and quantitative analysis
   Chunsheng Yan · 2025 · 188 citations
6. Investigation of Metal-Organic Frameworks (MOFs): Synthesis, Properties, and Applications - An In-Depth Review
   Fatima Zohra Zeggai, Zouhair Ait‐Touchente et al. · 2025 · 180 citations
7. Highly sensitive laser spectroscopy sensing based on a novel four-prong quartz tuning fork
   Runqiu Wang, Shunda Qiao et al. · 2025 · 168 citations
8. State‐of‐the‐Art, Insights, and Perspectives for MOFs‐Nanocomposites and MOF‐Derived (Nano)Materials
   Stefanos Mourdikoudis, Subhajit Dutta et al. · 2025 · 163 citations
9. Metal–organic framework-based smart stimuli-responsive drug delivery systems for cancer therapy: advances, challenges, and future perspectives
   Ziliang Guo, Yuzhen Xiao et al. · 2025 · 162 citations
10. Environmental applications of metal–organic framework-based three-dimensional macrostructures: a review
    Cheng Chen, Liguo Shen et al. · 2025 · 160 citations
11. Hyperspectral Imaging and Deep Learning for Quality and Safety Inspection of Fruits and Vegetables: A Review
    Yang Chen, Zhiming Guo et al. · 2025 · 151 citations
12. Pore engineering in metal–organic frameworks and covalent organic frameworks: strategies and applications
    Yanpei Song, Shengqian Ma · 2025 · 141 citations
13. ZIF-8 metal–organic frameworks and their hybrid materials: emerging photocatalysts for energy and environmental applications
    Diptirani Behera, Priyanka Priyadarshini et al. · 2025 · 135 citations
14. The Cation−π Interaction in Chemistry and Biology
    Dennis A. Dougherty · 2025 · 134 citations
15. Green Analytical Chemistry—Recent Innovations
    Anil Kumar Meher, Akli Zarouri · 2025 · 133 citations
16. Calibration-free measurement of absolute gas concentration and temperature via light-induced thermoelastic spectroscopy
    Shunda Qiao, Ziting Lang et al. · 2025 · 131 citations
17. Enhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics
    Zilu Ye, Pierre Sabatier et al. · 2025 · 129 citations · Free PDF
18. Visible light–triggered depolymerization of commercial polymethacrylates
    Hyun Suk Wang, Mikhail Agrachev et al. · 2025 · 128 citations
19. Parts-per-quadrillion level gas molecule detection: CO-LITES sensing
    Haiyue Sun, Shunda Qiao et al. · 2025 · 124 citations · Free PDF
20. Recent advances in MOF composites for photocatalysis
    Chenxi Zhang, Yanhong Wu et al. · 2025 · 124 citations
21. Molecular Photoelectrocatalysis for Radical Reactions
    Peng Xiong, Hai‐Chao Xu · 2025 · 119 citations
22. Porosity Tunable Metal-Organic Framework (MOF)-Based Composites for Energy Storage Applications: Recent Progress
    Huddad Laeim, Vandana Molahalli et al. · 2025 · 116 citations · Free PDF
23. Intermolecular 1,2-difunctionalization of alkenes
    Yuanrui Wang, Zhipeng Bao et al. · 2025 · 116 citations
24. Remodelling molecular frameworks via atom-level surgery: recent advances in skeletal editing of (hetero)cycles
    Rubal Sharma, Mitsuhiro Arisawa et al. · 2025 · 114 citations
25. Advances in Organic Small Molecule-Based Fluorescent Probes for Precision Detection of Liver Diseases: A Perspective on Emerging Trends and Challenges
    Luling Wu, Zilu Li et al. · 2025 · 113 citations

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