# Most-cited Chemistry papers of 2022, with free PDFs

The 25 most-cited Chemistry research papers published in 2022, ranked by citations in OpenAlex, with their original abstracts and free PDFs where available.

1. [Management of validation of HPLC method for determination of acetylsalicylic acid impurities in a new pharmaceutical product](https://nerdi.pages.dev/paper/W4205765055) · 2,120 citations · Free PDF
2. [Zeolites in Adsorption Processes: State of the Art and Future Prospects](https://nerdi.pages.dev/paper/W4306840209) · 1,113 citations · Free PDF
3. [Review on Metal–Organic Framework Classification, Synthetic Approaches, and Influencing Factors: Applications in Energy, Drug Delivery, and Wastewater Treatment](https://nerdi.pages.dev/paper/W4311376748) · 900 citations
4. [The ProteomeXchange consortium at 10 years: 2023 update](https://nerdi.pages.dev/paper/W4308834828) · 833 citations
5. [The ten principles of green sample preparation](https://nerdi.pages.dev/paper/W4205915025) · 720 citations
6. [Role of Lipids in Food Flavor Generation](https://nerdi.pages.dev/paper/W4292451742) · 676 citations · Free PDF
7. [A review on biological and medicinal impact of heterocyclic compounds](https://nerdi.pages.dev/paper/W4307568539) · 628 citations
8. [Metal Sites in Zeolites: Synthesis, Characterization, and Catalysis](https://nerdi.pages.dev/paper/W4294073912) · 625 citations
9. [Crystal Engineering of Pharmaceutical Cocrystals in the Discovery and Development of Improved Drugs](https://nerdi.pages.dev/paper/W4281730893) · 601 citations
10. [Chiral Metal–Organic Frameworks](https://nerdi.pages.dev/paper/W4220848631) · 583 citations
11. [Adsorption of iodine in metal–organic framework materials](https://nerdi.pages.dev/paper/W4224301973) · 565 citations
12. [Deep Visual Proteomics defines single-cell identity and heterogeneity](https://nerdi.pages.dev/paper/W4280598306) · 554 citations · Free PDF
13. [Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation](https://nerdi.pages.dev/paper/W4214546240) · 550 citations · Free PDF
14. [Metal Ion-Directed Functional Metal–Phenolic Materials](https://nerdi.pages.dev/paper/W4229456736) · 535 citations
15. [Hypocrystalline ceramic aerogels for thermal insulation at extreme conditions](https://nerdi.pages.dev/paper/W4283689033) · 526 citations · Free PDF
16. [Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook](https://nerdi.pages.dev/paper/W4211064536) · 510 citations
17. [A review of the modern principles and applications of solid-phase extraction techniques in chromatographic analysis](https://nerdi.pages.dev/paper/W4302013369) · 485 citations · Free PDF
18. [Construction and application of base-stable MOFs: a critical review](https://nerdi.pages.dev/paper/W4282963322) · 464 citations
19. [Uranium extraction from seawater: material design, emerging technologies and marine engineering](https://nerdi.pages.dev/paper/W4310784068) · 462 citations
20. [Ligand‐to‐Metal Charge Transfer (LMCT) Photochemistry at 3d‐Metal Complexes: An Emerging Tool for Sustainable Organic Synthesis](https://nerdi.pages.dev/paper/W4292790958) · 461 citations
21. [Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids](https://nerdi.pages.dev/paper/W4206169894) · 451 citations
22. [dia-PASEF data analysis using FragPipe and DIA-NN for deep proteomics of low sample amounts](https://nerdi.pages.dev/paper/W4284897468) · 448 citations · Free PDF
23. [Organocatalytic Atroposelective Synthesis of Indole Derivatives Bearing Axial Chirality: Strategies and Applications](https://nerdi.pages.dev/paper/W4294286674) · 447 citations
24. [Greenificated Molecularly Imprinted Materials for Advanced Applications](https://nerdi.pages.dev/paper/W4283323630) · 444 citations
25. [Multifunctional SiC@SiO2 Nanofiber Aerogel with Ultrabroadband Electromagnetic Wave Absorption](https://nerdi.pages.dev/paper/W4288445452) · 444 citations · Free PDF

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