# PLIP 2025: introducing protein–protein interactions to the protein–ligand interaction profiler

“PLIP 2025: introducing protein–protein interactions to the protein–ligand interaction profiler” (2025), by Philipp Schake et al. Computer Science research paper. Original abstract below, unchanged. No free PDF was found.

- Authors: Philipp Schake, Sarah Naomi Bolz, Katja L Linnemann, Michael D. Schroeder
- Published: May 9, 2025
- Field: Computer Science
- DOI: https://doi.org/10.1093/nar/gkaf361
- Source: https://doi.org/10.1093/nar/gkaf361

## Abstract

PLIP, the protein-ligand interaction profiler, analyses molecular interactions in protein structures. PLIP detects eight types of non-covalent interactions. Initially focused on small-molecule, DNA, and RNA interactions to a protein, the current release incorporates protein-protein interactions. We document the usefulness of this feature by comparing PLIP interactions of the cancer drug venetoclax with the native protein-protein interaction of Bcl-2 and BAX. PLIP reveals how the drug mimics the native interaction, as there is critical overlap in the interaction profiles. PLIP is available as a web server, source code with containers, and Jupyter notebook. The PLIP web server is online at https://plip-tool.biotec.tu-dresden.de.

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