# Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM

“Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM” (2025), by Oliver A. Cornely et al. Medicine research paper. Original abstract below, unchanged. A free PDF is available.

- Authors: Oliver A. Cornely, Rosanne Sprute, Matteo Bassetti, Wen Chen, Andreas H. Groll, Oliver Kurzai, Cornelia Lass‐Flörl, Luis Ostrosky‐Zeichner, Riina Rautemaa‐Richardson, Gunturu Revathi et al.
- Published: February 13, 2025
- Field: Medicine
- DOI: https://doi.org/10.1016/s1473-3099(24)00749-7
- Free PDF: https://lirias.kuleuven.be/retrieve/4cfc0f21-9518-42e6-8cc7-729a94d7b2b1

## Abstract

Candida species are the predominant cause of fungal infections in patients treated in hospital, contributing substantially to morbidity and mortality. Candidaemia and other forms of invasive candidiasis primarily affect patients who are immunocompromised or critically ill. In contrast, mucocutaneous forms of candidiasis, such as oral thrush and vulvovaginal candidiasis, can occur in otherwise healthy individuals. Although mucocutaneous candidiasis is generally not life-threatening, it can cause considerable discomfort, recurrent infections, and complications, particularly in patients with underlying conditions such as diabetes or in those taking immunosuppressive therapies. The rise of difficult-to-treat Candida infections is driven by new host factors and antifungal resistance. Pathogens, such as Candida auris (Candidozyma auris) and fluconazole-resistant Candida parapsilosis, pose serious global health risks. Recent taxonomic revisions have reclassified several Candida spp, potentially causing confusion in clinical practice. Current management guidelines are limited in scope, with poor coverage of emerging pathogens and new treatment options. In this Review, we provide updated recommendations for managing Candida infections, with detailed evidence summaries available in the appendix.

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