# UniProt: the Universal Protein Knowledgebase in 2025

“UniProt: the Universal Protein Knowledgebase in 2025” (2024), by Alex G. Bateman et al. Genetics and Biochemistry research paper. Original abstract below, unchanged. No free PDF was found.

- Authors: Alex G. Bateman, Maria Jesus Martin, Sandra E. Orchard, Michele Magrane, Aduragbemi S. Adesina, Shadab Ahmad, Emily Bowler-Barnett, Hema Bye‐A‐Jee, David C. J. Carpentier, PAUL C. DENNY et al.
- Published: October 16, 2024
- Field: Genetics and Biochemistry
- DOI: https://doi.org/10.1093/nar/gkae1010
- Source: https://doi.org/10.1093/nar/gkae1010

## Abstract

The aim of the UniProt Knowledgebase (UniProtKB; https://www.uniprot.org/) is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this publication, we describe ongoing changes to our production pipeline to limit the sequences available in UniProtKB to high-quality, non-redundant reference proteomes. We continue to manually curate the scientific literature to add the latest functional data and use machine learning techniques. We also encourage community curation to ensure key publications are not missed. We provide an update on the automatic annotation methods used by UniProtKB to predict information for unreviewed entries describing unstudied proteins. Finally, updates to the UniProt website are described, including a new tab linking protein to genomic information. In recognition of its value to the scientific community, the UniProt database has been awarded Global Core Biodata Resource status.

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