# Photocatalytic Late-Stage C–H Functionalization

“Photocatalytic Late-Stage C–H Functionalization” (2023), by Peter Bellotti et al. Chemistry research paper. Original abstract below, unchanged. No free PDF was found.

- Authors: Peter Bellotti, Huan‐Ming Huang, Teresa Faber, Frank Glorius
- Published: January 24, 2023
- Field: Chemistry
- DOI: https://doi.org/10.1021/acs.chemrev.2c00478
- Source: https://doi.org/10.1021/acs.chemrev.2c00478

## Abstract

The emergence of modern photocatalysis, characterized by mildness and selectivity, has significantly spurred innovative late-stage C-H functionalization approaches that make use of low energy photons as a controllable energy source. Compared to traditional late-stage functionalization strategies, photocatalysis paves the way toward complementary and/or previously unattainable regio- and chemoselectivities. Merging the compelling benefits of photocatalysis with the late-stage functionalization workflow offers a potentially unmatched arsenal to tackle drug development campaigns and beyond. This Review highlights the photocatalytic late-stage C-H functionalization strategies of small-molecule drugs, agrochemicals, and natural products, classified according to the targeted C-H bond and the newly formed one. Emphasis is devoted to identifying, describing, and comparing the main mechanistic scenarios. The Review draws a critical comparison between established ionic chemistry and photocatalyzed radical-based manifolds. The Review aims to establish the current state-of-the-art and illustrate the key unsolved challenges to be addressed in the future. The authors aim to introduce the general readership to the main approaches toward photocatalytic late-stage C-H functionalization, and specialist practitioners to the critical evaluation of the current methodologies, potential for improvement, and future uncharted directions.

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