# Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System

“Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System” (2022), by Raluca Ioana Teleanu et al. Neuroscience research paper. Original abstract below, unchanged. A free PDF is available.

- Authors: Raluca Ioana Teleanu, Adelina-Gabriela Niculescu, Eugenia Roza, Oana Aurelia Vladâcenco, Alexandru Mihai Grumezescu, Daniel Mihai Teleanu
- Published: May 25, 2022
- Field: Neuroscience
- DOI: https://doi.org/10.3390/ijms23115954
- Free PDF: https://www.mdpi.com/1422-0067/23/11/5954/pdf?version=1653553978

## Abstract

Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having an essential role in information transmission throughout the nervous system. Hundreds of such chemicals have been discovered in the last century, continuing to be identified and studied concerning their action on brain health. These substances have been observed to influence numerous functions, including emotions, thoughts, memories, learning, and movements. Thus, disturbances in neurotransmitters' homeostasis started being correlated with a plethora of neurological and neurodegenerative disorders. In this respect, the present paper aims to describe the most important neurotransmitters, broadly classified into canonical (e.g., amino acids, monoamines, acetylcholine, purines, soluble gases, neuropeptides) and noncanonical neurotransmitters (e.g., exosomes, steroids, D-aspartic acid), and explain their link with some of the most relevant neurological conditions. Moreover, a brief overview of the recently developed neurotransmitters' detection methods is offered, followed by several considerations on the modulation of these substances towards restoring homeostasis.

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