“Advances in the pathogenesis of psoriasis: from keratinocyte perspective” (2022), by Xue Zhou et al. Immunology and Microbiology research paper. Original abstract below, unchanged. A free PDF is available.

Advances in the pathogenesis of psoriasis: from keratinocyte perspective

Xue Zhou, Youdong Chen, Lian Cui et al. · January 24, 2022 · Immunology and Microbiology

Abstract

Psoriasis is a complex long-lasting inflammatory skin disease with high prevalence and associated comorbidity. It is characterized by epidermal hyperplasia and dermal infiltration of immune cells. Here, we review the role of keratinocytes in the pathogenesis of psoriasis, focusing on factors relevant to genetics, cytokines and receptors, metabolism, cell signaling, transcription factors, non-coding RNAs, antimicrobial peptides, and proteins with other different functions. The critical role of keratinocytes in initiating and maintaining the inflammatory state suggests the great significance of targeting keratinocytes for the treatment of psoriasis.

Free PDF DOI: 10.1038/s41419-022-04523-3