# Sensitive protein alignments at tree-of-life scale using DIAMOND

“Sensitive protein alignments at tree-of-life scale using DIAMOND” (2021), by Benjamin Buchfink et al. Genetics and Biochemistry research paper. Original abstract below, unchanged. A free PDF is available.

- Authors: Benjamin Buchfink, Klaus Reuter, Hajk‐Georg Drost
- Published: April 1, 2021
- Field: Genetics and Biochemistry
- DOI: https://doi.org/10.1038/s41592-021-01101-x
- Free PDF: https://www.nature.com/articles/s41592-021-01101-x.pdf

## Abstract

We are at the beginning of a genomic revolution in which all known species are planned to be sequenced. Accessing such data for comparative analyses is crucial in this new age of data-driven biology. Here, we introduce an improved version of DIAMOND that greatly exceeds previous search performances and harnesses supercomputing to perform tree-of-life scale protein alignments in hours, while matching the sensitivity of the gold standard BLASTP.

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