“Metal–Organic Frameworks for Drug Delivery: A Design Perspective” (2021), by Harrison Lawson et al. Chemistry research paper. Original abstract below, unchanged. No free PDF was found.

Metal–Organic Frameworks for Drug Delivery: A Design Perspective

Harrison Lawson, S. Patrick Walton, Christina Chan · February 7, 2021 · Chemistry

Abstract

The use of metal-organic frameworks (MOFs) in biomedical applications has greatly expanded over the past decade due to the precision tunability, high surface areas, and high loading capacities of MOFs. Specifically, MOFs are being explored for a wide variety of drug delivery applications. Initially, MOFs were used for delivery of small-molecule pharmaceuticals; however, more recent work has focused on macromolecular cargos, such as proteins and nucleic acids. Here, we review the historical application of MOFs for drug delivery, with a specific focus on the available options for designing MOFs for specific drug delivery applications. These options include choices of MOF structure, synthetic method, and drug loading. Further considerations include tuning, modifications, biocompatibility, cellular targeting, and uptake. Altogether, this Review aims to guide MOF design for novel biomedical applications.

Source page DOI: 10.1021/acsami.1c01089