# Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology

“Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology” (2020), by Aleksandra Zielińska et al. Materials Science research paper. Original abstract below, unchanged. A free PDF is available.

- Authors: Aleksandra Zielińska, Filipa Carreiró, Ana M. Oliveira, Andreia Neves, Bárbara Pires, D. Nagasamy Venkatesh, Alessandra Durazzo, Massimo Lucarini, Piotr Eder, Amélia Maria Silva et al.
- Published: August 15, 2020
- Field: Materials Science
- DOI: https://doi.org/10.3390/molecules25163731
- Free PDF: https://www.mdpi.com/1420-3049/25/16/3731/pdf?version=1597479221

## Abstract

Polymeric nanoparticles (NPs) are particles within the size range from 1 to 1000 nm and can be loaded with active compounds entrapped within or surface-adsorbed onto the polymeric core. The term "nanoparticle" stands for both nanocapsules and nanospheres, which are distinguished by the morphological structure. Polymeric NPs have shown great potential for targeted delivery of drugs for the treatment of several diseases. In this review, we discuss the most commonly used methods for the production and characterization of polymeric NPs, the association efficiency of the active compound to the polymeric core, and the in vitro release mechanisms. As the safety of nanoparticles is a high priority, we also discuss the toxicology and ecotoxicology of nanoparticles to humans and to the environment.

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