# A pneumonia outbreak associated with a new coronavirus of probable bat origin

“A pneumonia outbreak associated with a new coronavirus of probable bat origin” (2020), by Peng Zhou et al. Medicine research paper. Original abstract below, unchanged. A free PDF is available.

- Authors: Peng Zhou, Xing‐Lou Yang, Xian-Guang Wang, Xian-Guang Wang, Ben Hu, Wei Zhang, Wei Zhang, Hao-Rui Si, Yan Zhu, Bei Li et al.
- Published: February 3, 2020
- Field: Medicine
- DOI: https://doi.org/10.1038/s41586-020-2012-7
- Free PDF: https://www.nature.com/articles/s41586-020-2012-7.pdf

## Abstract

Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats 1–4 . Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans 5–7 . Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of . In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV.

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