# Inflammation and cancer

“Inflammation and cancer” (2019), by Nitin  Kumar Singh et al. Immunology and Microbiology research paper. Original abstract below, unchanged. No free PDF was found.

- Authors: Nitin  Kumar Singh, Deepak Baby, Jagadish Prasad Rajguru, Pankaj Bajirao Patil, Savita S Thakkannavar, Veena Bhojaraj Pujari
- Published: January 1, 2019
- Field: Immunology and Microbiology
- DOI: https://doi.org/10.4103/aam.aam_56_18
- Source: https://www.ncbi.nlm.nih.gov/pmc/articles/6704802

## Abstract

Inflammation is often associated with the development and progression of cancer. The cells responsible for cancer-associated inflammation are genetically stable and thus are not subjected to rapid emergence of drug resistance; therefore, the targeting of inflammation represents an attractive strategy both for cancer prevention and for cancer therapy. Tumor-extrinsic inflammation is caused by many factors, including bacterial and viral infections, autoimmune diseases, obesity, tobacco smoking, asbestos exposure, and excessive alcohol consumption, all of which increase cancer risk and stimulate malignant progression. In contrast, cancer-intrinsic or cancer-elicited inflammation can be triggered by cancer-initiating mutations and can contribute to malignant progression through the recruitment and activation of inflammatory cells. Both extrinsic and intrinsic inflammations can result in immunosuppression, thereby providing a preferred background for tumor development. The current review provides a link between inflammation and cancer development.

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