“Damage-Associated Molecular Patterns in Inflammatory Diseases” (2018), by Jong Seong Roh et al. Immunology and Microbiology research paper. Original abstract below, unchanged. No free PDF was found.

Damage-Associated Molecular Patterns in Inflammatory Diseases

Jong Seong Roh, Dong Hyun Sohn · January 1, 2018 · Immunology and Microbiology

Abstract

Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although DAMPs contribute to the host's defense, they promote pathological inflammatory responses. Recent studies have suggested that various DAMPs, such as high-mobility group box 1 (HMGB1), S100 proteins, and heat shock proteins (HSPs), are increased and considered to have a pathogenic role in inflammatory diseases. Here, we review current research on the role of DAMPs in inflammatory diseases, including rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, atherosclerosis, Alzheimer's disease, Parkinson's disease, and cancer. We also discuss the possibility of DAMPs as biomarkers and therapeutic targets for these diseases.

Source page DOI: 10.4110/in.2018.18.e27