“Nanoparticle‐Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy” (2018), by Xiaopin Duan et al. Immunology and Microbiology research paper. Original abstract below, unchanged. No free PDF was found.

Nanoparticle‐Mediated Immunogenic Cell Death Enables and Potentiates Cancer Immunotherapy

Xiaopin Duan, Christina Chan, Wenbin Lin · July 17, 2018 · Immunology and Microbiology

Abstract

Cancer immunotherapies that train or stimulate the inherent immunological systems to recognize, attack, and eradicate tumor cells with minimal damage to healthy cells have demonstrated promising clinical responses in recent years. However, most of these immunotherapeutic strategies only benefit a small subset of patients and cause systemic autoimmune side effects in some patients. Immunogenic cell death (ICD)-inducing modalities not only directly kill cancer cells but also induce antitumor immune responses against a broad spectrum of solid tumors. Such strategies for generating vaccine-like functions could be used to stimulate a "cold" tumor microenvironment to become an immunogenic, "hot" tumor microenvironment, working in synergy with immunotherapies to increase patient response rates and lead to successful treatment outcomes. This Minireview will focus on nanoparticle-based treatment modalities that can induce and enhance ICD to potentiate cancer immunotherapy.

Source page DOI: 10.1002/anie.201804882