# Lactobacillus reuteri induces gut intraepithelial CD4 + CD8αα + T cells

“Lactobacillus reuteri induces gut intraepithelial CD4 + CD8αα + T cells” (2017), by Luisa Cervantes‐Barragán et al. Immunology and Microbiology research paper. Original abstract below, unchanged. No free PDF was found.

- Authors: Luisa Cervantes‐Barragán, Jiani N. Chai, Ma. Diarey B. Tianero, Blanda Di Luccia, Philip P. Ahern, Joseph A. Merriman, Victor S. Cortez, Michael G. Caparon, Mohamed S. Donia, Susan Gilfillan et al.
- Published: August 3, 2017
- Field: Immunology and Microbiology
- DOI: https://doi.org/10.1126/science.aah5825
- Source: https://www.ncbi.nlm.nih.gov/pmc/articles/5687812

## Abstract

Tolerogenic T cells need probiotics CD4 + CD8αα + double-positive intraepithelial lymphocytes (DP IELs) are a recently discovered class of intestinal T cells believed to take part in a variety of immune responses, including oral tolerance. These cells are absent in germ-free mice, but the mechanisms driving their development are unclear. Cervantes-Barragan et al. found that a particular species of probiotic bacteria, Lactobacillus reuteri , induces DP IELs. This does not occur by stimulating the immune system directly. Instead, L. reuteri generates a specific derivative of dietary tryptophan that promotes differentiation of DP IEL precursors. These findings underscore the delicate interplay between benign bacteria, diet, and gut health. Science , this issue p. 806

Canonical page: https://nerdi.pages.dev/paper/W2743071411
Read three real papers a day in Nerdi (iPhone): https://apps.apple.com/app/apple-store/id6813826387?pt=128757794&ct=web-paper&mt=8