# NF-κB signaling in inflammation

“NF-κB signaling in inflammation” (2017), by Ting Liu et al. Genetics and Biochemistry research paper. Original abstract below, unchanged. A free PDF is available.

- Authors: Ting Liu, Lingyun Zhang, Donghyun Joo, Shao‐Cong Sun
- Published: July 14, 2017
- Field: Genetics and Biochemistry
- DOI: https://doi.org/10.1038/sigtrans.2017.23
- Free PDF: https://www.nature.com/articles/sigtrans201723.pdf

## Abstract

The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the expression of various pro-inflammatory genes, including those encoding cytokines and chemokines, and also participates in inflammasome regulation. In addition, NF-κB plays a critical role in regulating the survival, activation and differentiation of innate immune cells and inflammatory T cells. Consequently, deregulated NF-κB activation contributes to the pathogenic processes of various inflammatory diseases. In this review, we will discuss the activation and function of NF-κB in association with inflammatory diseases and highlight the development of therapeutic strategies based on NF-κB inhibition.

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